Risk differences for all outcomes were attenuated over time; risk for early neonatal death disappeared<\/p>\n<\/h3>\n
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TUESDAY, Feb. 8, 2022 (HealthDay News) — Women with cervical intraepithelial neoplasia grade 3 (CIN 3) have adverse pregnancy outcomes, although the risks have attenuated over time, according to a study published online Feb. 8 in the Annals of Internal Medicine<\/em>.<\/p>\n Wei He, Ph.D., from The Children’s Hospital in Hangzhou, China, and colleagues conducted a population- and sibling-matched cohort study to examine pregnancy outcomes among women diagnosed with CIN 3 in Sweden from 1973 to 2018. A total of 78,450 singletons born to women diagnosed with CIN 3 were compared to 784,500 matched singletons born to women in the general population. The sibling cohort included 23,199 singletons born to women diagnosed with CIN 3 and 28,135 singletons born to their sisters who did not have CIN 3.<\/p>\n The researchers found that women previously diagnosed with CIN 3 were more likely than the matched general population to have a preterm birth, especially extremely preterm birth (22 to 28 weeks: odds ratio, 3.00), or to have spontaneous preterm birth (odds ratio, 2.12); infection-related outcomes, including chorioamnionitis and infant sepsis (odds ratios, 3.23 and 1.72, respectively); or early neonatal death (odds ratio, 1.83). Results were largely similar for sibling comparison analyses. The risk differences for all outcomes were attenuated over time and disappeared for early neonatal death.<\/p>\n “These results suggest that women treated for CIN 3 should be recognized as ‘high-risk’ and managed accordingly to reduce the risk for adverse pregnancy outcomes,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n