Weight loss from age 20 to age 55 to 74 years was linked to reduced risk, especially for those who were overweight, obese<\/p>\n<\/h3>\n
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TUESDAY, Feb. 1, 2022 (HealthDay News) — Weight loss in adulthood is associated with reduced risk of incident distal colorectal adenoma, according to a study published online Feb. 1 in JNCI Cancer Spectrum<\/em>.<\/p>\n Shishi He, from the University of Maryland School of Medicine in Baltimore, and colleagues assessed weight change during early-late (age 20 to baseline [55 to 74 years]), early-middle (20 to 50 years), and middle-late (50 to baseline) adulthood in relation to incident distal adenoma in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (1,053 cases and 16,576 controls).<\/p>\n The researchers found that weight loss during early-late adulthood was associated with reduced adenoma risk compared with stable weight (odds ratio, 0.54; 95 percent confidence interval [CI], 0.34 to 0.86), especially for those who were overweight or obese at age 20 (odds ratio, 0.39; 95 percent CI, 0.18 to 0.84). Similar results were seen for early-middle adulthood, but were less pronounced for middle-late adulthood. Increased risk was seen in association with weight gain of more than 3 kg in five years during early-late adulthood (odds ratio, 1.30; 95 percent CI, 1.07 to 1.58). The findings were stronger for men (odds ratio, 1.41; 95 percent CI, 1.11 to 1.80) than for women (odds ratio, 1.09; 95 percent CI, 0.79 to 1.50).<\/p>\n “Based on our findings, we would not recommend weight loss for all adults,” a coauthor said in a statement. “But the results suggest that overweight and obese adults may benefit from weight loss.”<\/p>\n