Reporting rates 3.83 per million vaccine doses for Ad26.COV2.S versus 0.00855 per million for mRNA-based vaccines<\/p>\n<\/h3>\n
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FRIDAY, Jan. 28, 2022 (HealthDay News) — The rate of thrombosis with thrombocytopenia syndrome (TTS) is higher after receipt of the Ad26.COV2.S vaccine than mRNA-based COVID-19 vaccines, according to a case series published online Jan. 18 in the Annals of Internal Medicine<\/em>.<\/p>\n Isaac See, M.D., from the U.S. Centers for Disease Control and Prevention COVID-19 Response Team in Atlanta, and colleagues present surveillance data and reporting rates of all TTS cases after COVID-19 vaccination from Dec. 14, 2020, through Aug. 31, 2021, reported to the U.S. Vaccine Adverse Event Reporting System.<\/p>\n The researchers found that 57 TTS cases were confirmed after vaccination with Ad26.COV2.S or an mRNA-based COVID-19 vaccine (54 and three, respectively). The reporting rates were 3.83 and 0.00855 per million vaccine doses for Ad26.COV2.S and mRNA-based COVID-19 vaccines, respectively. For patients with TTS after Ad26.COV2.S, the median patient age was 44.5 years; 69 percent were women. Two of the three TTS cases after mRNA-based COVID-19 vaccination occurred in men older than 50 years and one occurred in a woman aged 50 to 59 years. All patients with TTS after Ad26.COV2.S vaccination were hospitalized; 67 percent had intensive care unit admission. Outcomes of hospitalization included death, discharge to postacute care, and discharge home (15, 17, and 68 percent, respectively).<\/p>\n “See and colleagues persuasively show that there are real differences in the frequency of TTS (or vaccine-induced immune thrombotic thrombocytopenia) between the Ad26.COV2.S and mRNA vaccines, thus supporting the decision by the Centers for Disease Control and Prevention to favor the mRNA-based vaccines,” write the authors of an accompanying editorial.<\/p>\n Several authors disclosed financial ties to the biopharmaceutical, medical device, and medical technology industries.<\/p>\n Abstract\/Full Text<\/a> <\/p>\n