Three-day course of treatment results in reduced risk for hospitalization or death compared with placebo<\/p>\n<\/h3>\n
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THURSDAY, Dec. 23, 2021 (HealthDay News) — A three-day course of remdesivir results in a lower risk for hospitalization or death compared with placebo among nonhospitalized patients at high risk for COVID-19 progression, according to a study published online Dec. 22 in the New England Journal of Medicine<\/em>.<\/p>\n Robert L. Gottlieb, M.D., Ph.D., from the Baylor University Medical Center in Dallas, and colleagues conducted a randomized trial involving nonhospitalized patients with COVID-19 with symptom onset within the previous seven days and with at least one risk factor for disease progression. Patients were randomly assigned to receive intravenous remdesivir (200 mg on day 1; 100 mg on days 2 and 3) or placebo (279 and 283 patients, respectively).<\/p>\n The researchers found that two patients in the remdesivir group and 15 in the placebo group had COVID-19-related hospitalization or death (0.7 versus 5.3 percent; hazard ratio, 0.13). By day 28, 1.6 and 8.3 percent of patients in the remdesivir and placebo groups, respectively, had a COVID-19-related medically attended visit (hazard ratio, 0.19); there were no deaths by day 28. Adverse events occurred in 42.3 and 46.3 percent of those in the remdesivir and placebo groups, respectively.<\/p>\n “In the campaign toward ending the COVID-19 pandemic, these data add yet another option to the armamentarium for the treatment of vulnerable patients who are at high risk for progression to severe COVID-19,” the authors write.<\/p>\n The study was funded by Gilead Sciences, the manufacturer of remdesivir.<\/p>\n Abstract\/Full Text<\/a><\/p>\n