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THURSDAY, June 14, 2018 (HealthDay News) — In utero exposure to type 2 diabetes is associated with increased risk of type 2 diabetes in offspring versus exposure to gestational diabetes, according to a study published online June 11 in JAMA Pediatrics<\/i>.<\/p>\n
Brandy A. Wicklow, M.D., from the University of Manitoba in Winnipeg, Canada, and colleagues examined the correlation of in utero exposure to gestational diabetes and type 2 diabetes with the development of type 2 diabetes in offspring, stratified by First Nations (FN) status. A pediatric diabetes clinical database was linked to a population-based research data repository; the cohort study included 467,850 offspring.<\/p>\n
The researchers found that after adjustment for sex, maternal age, socioeconomic status, birth size, and gestational age, FN status and diabetes exposure were correlated with incident type 2 diabetes in offspring. The risk to offspring was greater with type 2 diabetes exposure versus gestational diabetes exposure (3.19 versus 0.8 cases per 1,000 person-years). Any diabetes exposure was correlated with accelerated time to the development of type 2 diabetes in offspring by a factor of 0.74 and 0.5 for gestational diabetes and type 2 diabetes, respectively, compared with no diabetes exposure. Risk was higher for FN offspring versus non-FN offspring (0.96 versus 0.14 cases per 1,000 person-years). The interactions between FN and type 2 diabetes and FN and gestational diabetes were not significant.<\/p>\n
“Important differences exist in offspring risk based on type of diabetes exposure in utero,” the authors write.<\/p>\n