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FRIDAY, June 8, 2018 (HealthDay News) — At hospitals with the lowest volume of immunosuppressed patients with sepsis, the risk of death from sepsis due to a suppressed immune state is highest, according to a study published online June 1 in the Annals of the American Thoracic Society<\/i>.<\/p>\n
Jared A. Greenberg, M.D., from the Rush University Medical Center in Chicago, and colleagues characterized patients with sepsis at hospitals according to immune state. Variation in the odds of in-hospital death from sepsis due to a suppressed immune state was examined based on the average volume of immunosuppressed patients with sepsis each year.<\/p>\n
The researchers identified 350,183 patients with sepsis at 60 hospitals from 2010 to 2012. Compared with non-immunosuppressed patients with sepsis, immunosuppressed patients with sepsis at the 15 hospitals in the first quartile had increased odds of in-hospital death (adjusted odds ratio, 1.38). For patients at hospitals in the second, third, and fourth quartiles, the odds of in-hospital death for immunosuppressed patients with sepsis relative to non-immunosuppressed patients with sepsis was similar. The adjusted odds of death from sepsis due to a suppressed immune state (odds ratio, 1.21) was significantly lower for these 45 hospitals analyzed as a group relative to that for the patients at the 15 hospitals in the first quartile (P = 0.004 for difference).<\/p>\n
“The risk of death from sepsis due to a suppressed immune state was greatest at hospitals with the lowest volume of immunosuppressed patients with sepsis,” the authors write.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n