Adjusted odds ratio for type 2 diabetes further reduced for those with more than eight years of alendronate use<\/p>\n<\/h3>\n
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TUESDAY, Sept. 28, 2021 (HealthDay News) — Alendronate seems to reduce the risk for type 2 diabetes, according to a study presented at the annual meeting of the European Association for the Study of Diabetes, held virtually from Sept. 28 to Oct. 1.<\/p>\n
Rikke Viggers and Peter Vestergaard, M.D., Ph.D., from Aalborg University Hospital in Denmark, conducted a population-based case-control study to examine whether the risk for developing type 2 diabetes is altered by previous alendronate use. All cases with a diagnosis of type 2 diabetes between 2008 and 2018 were matched with three randomly selected controls based on sex and age by incidence-density sampling. Data were included for 163,588 patients with type 2 diabetes and 490,764 matched controls.<\/p>\n
The researchers found that after alendronate use, the crude odds ratio for developing type 2 diabetes was 0.93; this was further attenuated after adjustment (multiple adjusted odds ratio, 0.64). Among those with more than eight years of alendronate use, the adjusted odds ratio decreased to 0.47. There was a dose-response relationship noted between longer effective alendronate use and a reduced risk for type 2 diabetes.<\/p>\n
“Excitingly, our research suggests that alendronate, an inexpensive medicine widely used to treat osteoporosis, may also protect against type 2 diabetes,” Viggers said in a statement. “We believe that doctors should consider this when prescribing osteoporosis drugs to those with prediabetes or at high risk of type 2 diabetes.”<\/p>\n
Viggers disclosed financial ties to Novo Nordisk Foundation, which funded the study.<\/p>\n
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