Reduction in clinic systolic BP and reduction in 24-hour ambulatory systolic BP greater with Center-Based Lifestyle Intervention<\/p>\n<\/h3>\n
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MONDAY, Sept. 27, 2021 (HealthDay News) — For patients with resistant hypertension, a four-month structured program of diet and exercise results in significant reductions in clinic and ambulatory blood pressure (BP), according to a study published online Sept. 27 in Circulation<\/em>.<\/p>\n James A. Blumenthal, Ph.D., from the Duke University Medical Center in Durham, North Carolina, and colleagues randomly assigned 140 patients with resistant hypertension to a four-month program of lifestyle modification, including dietary counseling, behavioral weight management, and exercise (Center-Based Lifestyle Intervention [C-LIFE]) or a single counseling session providing Standardized Education and Physician Advice (SEPA). Clinic systolic BP was measured as the primary end point.<\/p>\n The researchers found that compared with SEPA, the reduction in clinic systolic BP was greater in C-LIFE (\u00e2\u0088\u009212.5 versus \u00e2\u0088\u00927.1 mm Hg); there was also a reduction in 24-hour ambulatory systolic BP compared with no change in SEPA (\u00e2\u0088\u00927.0 versus \u00e2\u0088\u00920.3 mm Hg). C-LIFE resulted in greater improvements in resting baroreflex sensitivity (2.3 versus \u00e2\u0088\u00921.1 ms\/mm Hg), high-frequency heart rate variability (0.4 versus \u00e2\u0088\u00920.2 Ln ms2<\/sup>), and flow-mediated dilation (0.3 versus \u00e2\u0088\u00921.4 percent) compared with SEPA. The investigators noted that pulse wave velocity and left ventricular mass were not different between the groups.<\/p>\n “While some people can make lifestyle changes on their own, a structured program of supervised exercise and dietary modifications conducted by a multidisciplinary team of health care professionals in cardiac rehabilitation programs is likely more effective,” Blumenthal said in a statement.<\/p>\n