{"id":6258,"date":"2018-06-05T00:00:00","date_gmt":"2018-06-05T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2018\/06\/05\/similar-primary-outcome-for-lower-o2-sat-in-extreme-preterm\/"},"modified":"2018-06-06T16:09:49","modified_gmt":"2018-06-06T16:09:49","slug":"similar-primary-outcome-for-lower-o2-sat-in-extreme-preterm","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2018\/06\/05\/similar-primary-outcome-for-lower-o2-sat-in-extreme-preterm\/","title":{"rendered":"Similar Primary Outcome for Lower O<sub>2<\/sub> Sat in Extreme Preterm"},"content":{"rendered":"<h3>No significant difference in composite outcome of death, major disability for extremely preterm infants<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>TUESDAY, June 5, 2018 (HealthDay News) &#8212; Different target ranges for oxygen saturation as measured by pulse oximetry (SpO<sub>2<\/sub>) do not affect the composite primary outcome of death or major disability for extremely preterm infants, according to research published in the June 5 issue of the <i>Journal of the American Medical Association<\/i>.<\/p>\n<p>Lisa M. Askie, Ph.D., from the University of Sydney, and colleagues conducted a prospectively planned meta-analysis of individual participant data from five randomized clinical trials involving infants born before 28 weeks&#8217; gestation. Participants were randomized to lower (85 to 89 percent; 2,480 infants) or higher (91 to 95 percent; 2,485 infants) target ranges for SpO<sub>2<\/sub>.<\/p>\n<p>The researchers found that the primary outcome (composite of death or disability at a corrected age of 18 to 24 months) occurred in 53.5 and 51.6 percent of the lower and higher SpO<sub>2<\/sub> target groups, respectively (relative risk, 1.04; 95 percent confidence interval, 0.98 to 1.09; P = 0.21). Death occurred in 19.9 and 17.1 percent of infants in the lower and higher SpO<sub>2<\/sub> groups, respectively (relative risk, 1.17; 95 percent confidence interval, 1.04 to 1.31; P = 0.01). Severe necrotizing enterocolitis occurred in significantly more infants in the lower SpO<sub>2<\/sub> target group.<\/p>\n<p>&#8220;There was no significant difference between a lower SpO<sub>2<\/sub> target range compared with a higher SpO<sub>2<\/sub> target range on the primary composite outcome of death or major disability at a corrected age of 18 to 24 months,&#8221; the authors write.<\/p>\n<p>Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2683220\" target=\"_new\">Abstract\/Full Text<\/a><\/p>\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/2683197\" target=\"_new\">Editorial (subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2018 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\">HealthDay<\/a>. All rights reserved.<\/i>   <\/p>\n","protected":false},"excerpt":{"rendered":"<p>No significant difference in composite outcome of death, major disability for extremely preterm infants<\/p>\n","protected":false},"author":6,"featured_media":6278,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-6258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/6258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=6258"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/6258\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/6278"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=6258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=6258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=6258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}