But placebo-controlled trial shows lower all-cause mortality at 28 days and 60 days in patients receiving baricitinib plus standard of care<\/p>\n<\/h3>\n
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WEDNESDAY, Sept. 8, 2021 (HealthDay News) — For hospitalized adults with COVID-19, treatment with baricitinib in addition to standard of care does not reduce the frequency of disease progression overall, but it is associated with reduced mortality, according to a study published online Sept. 1 in The Lancet Respiratory Medicine<\/em>.<\/p>\n Vincent C. Marconi, M.D., from Emory University School of Medicine in Atlanta, and colleagues conducted a phase 3, double-blind trial involving participants from 101 centers across 12 countries. Hospitalized adults with COVID-19 receiving standard of care were randomly assigned to once-daily baricitinib or matched placebo (764 and 761, respectively) for up to 14 days. The proportion of patients who progressed to high-flow oxygen, noninvasive ventilation, invasive mechanical ventilation, or death by 28 days was the composite primary end point.<\/p>\n The researchers found that 27.8 and 30.5 percent of participants receiving baricitinib and placebo, respectively, progressed to meet the primary end point (odds ratio, 0.85; 95 percent confidence interval, 0.67 to 1.08; P = 0.18). The 28-day all-cause mortality rate was 8 and 13 percent for baricitinib and placebo, respectively (hazard ratio, 0.57; 95 percent confidence interval, 0.41 to 0.78; nominal P = 0.0018); per 20 baricitinib-treated patients, one additional death was prevented. The 60-day all-cause mortality was 10 and 15 percent for baricitinib and placebo, respectively (hazard ratio, 0.62; 95 percent confidence interval, 0.47 to 0.83; P = 0.0050). The two groups had similar frequencies of serious adverse events, serious infections, and venous thromboembolic events.<\/p>\n “Baricitinib plus standard of care could be a treatment option to reduce overall deaths in the context of the global burden of mortality during the COVID-19 pandemic,” the authors write.<\/p>\n Several authors disclosed financial ties to pharmaceutical companies, including Eli Lilly and Company, which manufactures baricitinib and funded the study, under license from Incyte Corporation.<\/p>\n Abstract\/Full Text<\/a><\/p>\n