Inverse association significant and stronger for dietary sources of vitamin D versus supplemental vitamin D<\/p>\n<\/h3>\n
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MONDAY, Aug. 30, 2021 (HealthDay News) — Higher vitamin D intake is associated with reduced risk of early-onset colorectal cancer (CRC) and precursors among young women, according to a study recently published in Gastroenterology<\/em>.<\/p>\n Hanseul Kim, from the Harvard T. H. Chan School of Public Health in Boston, and colleagues examined the association between total vitamin D intake and risks of early-onset CRC and precursors diagnosed before age 50 among women enrolled in the Nurses’ Health Study II.<\/p>\n During 1,250,560 person-years of follow-up from 1991 to 2015, the researchers documented 111 incident cases of early-onset CRC. There was a significant association seen for higher total vitamin D intake with reduced risk of early-onset CRC (hazard ratio for \u00e2\u0089\u00a5450 versus <300 IU\/day, 0.49). Per 400 IU\/day increase, the hazard ratio was 0.46. The inverse association was significant and was stronger for dietary sources of vitamin D than supplemental vitamin D. Per 400 IU\/day increase, the odds ratios for CRC precursors were 0.76 and 0.85 for conventional adenoma and serrated polyp, respectively.<\/p>\n “Our results further support that avoiding low vitamin D status is important in younger adults for health and possibly CRC prevention,” the authors write. “If confirmed, our findings could potentially lead to recommendations for higher vitamin D intake as an inexpensive, low-risk complement to CRC screening as CRC prevention strategies for adults younger than age 50.”<\/strong><\/p>\n Several authors disclosed financial ties to the biopharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n