New index shows strong correlation with endoscopically determined disease activity<\/p>\n<\/h3>\n
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FRIDAY, Aug. 27, 2021 (HealthDay News) — A new ulcerative colitis intestinal ultrasound (UC-IUS) index shows strong correlation with endoscopy for detection of disease activity, according to a study published in the August issue of the Journal of Crohn’s and Colitis<\/em>.<\/p>\n Steven Bots, M.D., from the Amsterdam University Medical Center, and colleagues developed an ultrasonographic activity index using endoscopy as the reference standard (evaluation of 207 colonic segments in 60 patients).<\/p>\n The researchers found that bowel wall thickness (BWT) >2.1 mm was optimal to discriminate between Mayo 0 and Mayo 1 to 3 (sensitivity, 82.6 percent; specificity, 93.0 percent; area under the curve, 0.910), while a cutoff of 3.2 mm was optimal to discriminate between Mayo 0 to 1 and Mayo 2 to 3 (sensitivity, 89.1 percent; specificity, 92.3 percent; area under the curve, 0.946). For Mayo 3, BWT >3.9 mm was optimal (sensitivity, 80.6 percent; specificity, 84.1 percent; area under the curve, 0.909). Active disease was predicted by the presence of color Doppler signal (CDS). Stretches of CDS were associated with Mayo 2 to 3, lack of haustrations predicted active disease, and fat wrapping was associated with severe disease. There was a strong correlation noted between the index and endoscopic disease activity.<\/p>\n “We showed that IUS could be a reliable substitute for endoscopy for assessing disease activity in UC patients, except in patients with proctitis,” the authors write.<\/p>\n