Secondary analysis of randomized trial shows no difference in progression of KDIGO risk scores with daily vitamin D versus placebo<\/p>\n<\/h3>\n
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THURSDAY, Aug. 26, 2021 (HealthDay News) — Vitamin D supplementation does not impact kidney outcomes in a population of individuals with a high risk for type 2 diabetes, according to a study published online Aug. 6 in the Clinical Journal of the American Society of Nephrology<\/em>.<\/p>\n Sun H. Kim, M.D., from the Stanford University School of Medicine in California, and colleagues examined the effect of vitamin D supplementation on kidney outcomes in a population of overweight\/obese adults with a high risk for type 2 diabetes. A total of 2,166 participants were randomly assigned to vitamin D3<\/sub> or placebo for a median duration of 2.9 years.<\/p>\n The researchers found 28 and 30 cases of worsening of the Kidney Disease: Improving Global Outcomes risk score in the vitamin D and placebo groups, respectively (hazard ratio, 0.89; 95 percent confidence interval, 0.52 to 1.52). The mean difference in estimated glomerular filtration rate from baseline was \u00e2\u0088\u00921.0 mL\/min\/1.73 m2<\/sup> in the vitamin D group and \u00e2\u0088\u00920.1 mL\/min\/1.73 m2<\/sup> in the placebo group (between-group difference, \u00e2\u0088\u00921.0 mL\/min\/1.73 m2<\/sup>; 95 percent confidence interval, \u00e2\u0088\u00921.4 to \u00e2\u0088\u00920.6). In the vitamin D and placebo groups, the mean difference in urine albumin-to-creatinine ratios was 2.7 mg\/g and 2.0 mg\/g, respectively (between group difference, 0.7 mg\/g; 95 percent confidence interval, \u00e2\u0088\u00921.5 to 2.9).<\/p>\n “The majority of the study population had sufficient blood vitamin D levels and normal kidney function,” Kim said in a statement. “Benefits of vitamin D might be greater in people with low blood vitamin D levels and\/or reduced kidney function.”<\/p>\n Several authors disclosed financial ties to the biopharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n