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Here are what the editors at HealthDay consider to be the most important developments in Pathology for May 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
FDA Issues Final Guidance on Inhalational Anthrax<\/font><\/p>\n THURSDAY, May 31, 2018 (HealthDay News) — Final guidance has been issued by the U.S. Food and Drug Administration to assist in the development of drugs for the prevention of inhalational anthrax for individuals who may have been exposed but who have not yet displayed related signs or symptoms.<\/p>\n More Information<\/a><\/p>\n Oral Propranolol Seems Safe for Infantile Hemangioma<\/font><\/p>\n THURSDAY, May 31, 2018 (HealthDay News) — The safety profile of oral propranolol seems to be good for children with infantile hemangioma, according to a study published online May 29 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n ACS Updates Colorectal Cancer Screening to Start at Age 45<\/font><\/p>\n WEDNESDAY, May 30, 2018 (HealthDay News) — Colorectal cancer (CRC) screening should begin at age 45 for people at average risk, according to updated guidelines from the American Cancer Society published online May 30 in CA: A Cancer Journal for Clinicians<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Genomic Medicine Will Help Shift Cardio Care to Proactive Approach<\/font><\/p>\n WEDNESDAY, May 30, 2018 (HealthDay News) — Genomic medicine is likely to help clinical care shift from a reactive to a proactive approach, especially in the field of cardiovascular medicine, according to a scientific statement from the American Heart Association published online May 29 in Circulation: Genomic and Precision Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Worse Survival for BRCA<\/i> Germline Mutation Carriers in Pancreatic CA<\/font><\/p>\n WEDNESDAY, May 30, 2018 (HealthDay News) — BRCA1\/BRCA2<\/i> germline mutation carriers with pancreatic ductal adenocarcinoma (PDAC) have worse survival after resection, according to a study published in the April issue of the Journal of the American College of Surgeons<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Prediction Tool Helps Tailor Lung Cancer Screening to Patients<\/font><\/p>\n TUESDAY, May 29, 2018 (HealthDay News) — Personalizing the harm-benefit assessment of low-dose computed tomography (LDCT) screening for lung cancer can inform patient-centered screening decisions, according to a study published online May 29 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n FDA Approves Palynziq for Phenylketonuria<\/font><\/p>\n FRIDAY, May 25, 2018 (HealthDay News) — Palynziq (pegvaliase-pqpz) has been approved by the U.S. Food and Drug Administration to treat phenylketonuria, or PKU.<\/p>\n More Information<\/a><\/p>\n Increase in Tx Candidates With 2017 Hypertension Guidelines<\/font><\/p>\n FRIDAY, May 25, 2018 (HealthDay News) — The 2017 American College of Cardiology\/American Heart Association hypertension guideline is associated with an increase in the proportion of adults recommended for antihypertensive treatment compared with the 2014 guideline, according to a study published online May 23 in JAMA Cardiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial 1 (subscription or payment may be required)<\/a><\/p>\n Editorial 2 (subscription or payment may be required)<\/a><\/p>\n CDC IDs Outbreak Trends Tied to Treated Recreational Water<\/font><\/p>\n FRIDAY, May 25, 2018 (HealthDay News) — Outbreaks associated with treated recreational water with confirmed infectious etiology are usually caused by Cryptosporidium<\/i>, Legionella<\/i>, or Pseudomonas<\/i>, according to research published in the May 18 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Severe Atopic Eczema Tied to Higher CV Disease Risk<\/font><\/p>\n FRIDAY, May 25, 2018 (HealthDay News) — Adults with severe atopic eczema are at increased risk of cardiovascular disease, according to a study published online May 23 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Congress Approves Bill Expanding Private Care for VA Patients<\/font><\/p>\n THURSDAY, May 24, 2018 (HealthDay News) — Patients served by the beleaguered Veterans Affairs health system may have wider access to private care, thanks to a bill approved Wednesday by the Senate. President Donald Trump is known to support the bill, which now awaits his signature.<\/p>\n AMA Statement<\/a><\/p>\n More Information<\/a><\/p>\n Neurologists Identify New Type of Vertigo<\/font><\/p>\n THURSDAY, May 24, 2018 (HealthDay News) — A hyperactive and asymmetric velocity-storage mechanism may be responsible for intermittent attacks of vertigo in some patients with recurrent spontaneous vertigo (RSV) of unknown etiology, according to a study published online May 23 in Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Ingestible Bio-Electronic Device Could Monitor GI Health<\/font><\/p>\n THURSDAY, May 24, 2018 (HealthDay News) — An ingestible micro-bio-electronic device (IMBED) could be used for in situ biomolecular detection based on environmentally resilient biosensor bacteria and luminescence readout electronics, according to a study published in the May 25 issue of Science<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Global Variation in Personal Health Care Access and Quality<\/font><\/p>\n THURSDAY, May 24, 2018 (HealthDay News) — There is considerable global variation in personal health care access and quality, according to a study published online May 23 in The Lancet<\/i>.<\/p>\n Abstract<\/a><\/p>\n Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n PSA Level Three Months After Radiation Tx May Predict Outcome<\/font><\/p>\n THURSDAY, May 24, 2018 (HealthDay News) — Prostate-specific antigen (PSA) levels three months after radiotherapy (RT) are strong markers of prostate cancer outcomes for patients with intermediate- and high-risk disease, according to a study published online May 4 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Inverse Link for Plasma 25(OH)D Concentration, Risk of T2DM<\/font><\/p>\n WEDNESDAY, May 23, 2018 (HealthDay News) — There is an inverse association for plasma 25-hydroxyvitamin D (25[OH]D) concentration with diabetes risk, according to a study published online April 19 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n From 2008 to 2014, Prostate Cancer Testing, Treatment Down<\/font><\/p>\n TUESDAY, May 22, 2018 (HealthDay News) — Fewer men are being screened for, diagnosed with, and treated for prostate cancer, according to a study published online May 21 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n IBD Associated With Increased Risk of Parkinson’s Disease<\/font><\/p>\n TUESDAY, May 22, 2018 (HealthDay News) — There is a significantly increased risk of Parkinson’s disease (PD) in patients with inflammatory bowel disease (IBD), according to a study published online May 21 in Gut<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n CDC: No Change in Level of Uninsured in U.S. in 2017<\/font><\/p>\n TUESDAY, May 22, 2018 (HealthDay News) — Overall, 9.1 percent of individuals in the United States were uninsured in 2017, which was not significantly different from the level in 2016, according to a report published online May 22 by the U.S. Centers for Disease Control and Prevention’s National Centers for Health Statistics.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Language Used in Medical Record Can Affect Patient Care<\/font><\/p>\n FRIDAY, May 18, 2018 (HealthDay News) — Stigmatizing language used in medical records to describe patients can influence medical students and residents in terms of their attitudes towards the patient and their clinical decision-making, according to a study published in the May issue of the Journal of General Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Two Novel Immune-Response Clusters Identified to RSV<\/font><\/p>\n FRIDAY, May 18, 2018 (HealthDay News) — Two novel immune-response clusters have been identified to respiratory syncytial virus (RSV), and they are associated with first- and second-year recurrent wheeze, according to a study published online May 7 in the American Journal of Respiratory and Critical Care Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Breath Test Shows Promise for Diagnosis of Esophagogastric CA<\/font><\/p>\n FRIDAY, May 18, 2018 (HealthDay News) — Breath analysis shows potential for noninvasive diagnosis of esophagogastric cancer (OGC), according to a study published online May 17 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Molecular Basis for Varied Presentations of ETEC Explored<\/font><\/p>\n FRIDAY, May 18, 2018 (HealthDay News) — The EtpA adhesion molecule, which is secreted by enterotoxigenic Escherichia coli<\/i> (ETEC) strain H10407, is a dominant ETEC blood group A-specific lectin\/hemagglutinin, according to a study published online May 17 in the Journal of Clinical Investigation<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n V600E BRAF<\/i> Mutation Tied to Worse Survival in CRC Liver Mets<\/font><\/p>\n FRIDAY, May 18, 2018 (HealthDay News) — For patients undergoing resection of colorectal liver metastases (CRLM), the presence of the V600E BRAF<\/i> mutation is associated with worse prognosis, according to a study published online May 16 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n More Variants in DCM-Tied Genes in Alcoholic Cardiomyopathy<\/font><\/p>\n THURSDAY, May 17, 2018 (HealthDay News) — Patients with alcoholic cardiomyopathy (ACM) have more variants in dilated cardiomyopathy (DCM)-associated genes than those without ACM, according to a study published in the May 22 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Better Diet Quality Associated With Larger Brain Volume<\/font><\/p>\n WEDNESDAY, May 16, 2018 (HealthDay News) — Better diet quality, including high intake of vegetables, fruit, whole grains, dairy, nuts, and fish, is associated with larger brain volume, according to a study published online May 16 in Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Nonprofit Manufacturer Could Keep Generic Drug Costs Down<\/font><\/p>\n WEDNESDAY, May 16, 2018 (HealthDay News) — A nonprofit manufacturer could help keep generic drug prices down and maintain their supply, according to a perspective piece published in the May 17 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n New Rabies Test Could Radically Change Testing, Treatment<\/font><\/p>\n WEDNESDAY, May 16, 2018 (HealthDay News) — A new rapid rabies test for animals could revolutionize screening and spare humans unnecessary painful treatment, according to a U.S. Centers for Disease Control and Prevention study published online May 16 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n More Information<\/a><\/p>\n PPD Skin Test Enhances Bacillus Calmette-Gu\u00e9rin Tx in Bladder CA<\/font><\/p>\n WEDNESDAY, May 16, 2018 (HealthDay News) — For patients with non-muscle invasive bladder cancer, undergoing the purified protein derivative skin test prior to bacillus Calmette-Gu\u00e9rin therapy may have therapeutic impact, according to a study published in the June issue of The Journal of Urology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Higher CRC Risk With Advanced Adenoma Found on Colonoscopy<\/font><\/p>\n WEDNESDAY, May 16, 2018 (HealthDay News) — Participants with an advanced adenoma at diagnostic colonoscopy have increased risk of developing colorectal cancer (CRC) relative to those with no adenoma, according to a study published in the May 15 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n High Occupational Exercise Level Tied to Early Mortality in Men<\/font><\/p>\n TUESDAY, May 15, 2018 (HealthDay News) — High levels of occupational physical activity in men are associated with an increased risk of early mortality, according to a review published online May 14 in the British Journal of Sports Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Asthma Mortality Inversely Tied to Deprivation in English Young<\/font><\/p>\n TUESDAY, May 15, 2018 (HealthDay News) — For children and younger adults with asthma, prevalence and admissions increase with deprivation, while mortality is inversely associated with deprivation, according to a study published online May 14 in Thorax<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Assisted Reproduction May Up Risk of Placental Anomalies<\/font><\/p>\n TUESDAY, May 15, 2018 (HealthDay News) — Among singleton pregnancies, assisted reproductive technology (ART) is associated with an increased risk of placental anomalies, according to a review published online May 8 in BJOG: An International Journal of Obstetrics & Gynaecology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Use of Systematic Reviews Affects Newborn Screening Policy<\/font><\/p>\n TUESDAY, May 15, 2018 (HealthDay News) — Use of systematic review methodology is associated with reduced likelihood of screening for rare diseases using the newborn blood spot test being recommended, according to a meta-analysis published online May 9 in The BMJ<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Risk Models Help Select Ever Smokers for Lung CA Screening<\/font><\/p>\n MONDAY, May 14, 2018 (HealthDay News) — Four lung cancer risk models perform best in selecting ever-smokers for screening, according to a study published online May 15 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Maternal Exposure to Polluted Air Tied to Elevated Child BP<\/font><\/p>\n MONDAY, May 14, 2018 (HealthDay News) — Exposure to ambient air pollution in the third trimester of pregnancy is associated with increased risk of elevated blood pressure (BP) among offspring, according to a study published online May 14 in Hypertension<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Anxiety Levels Tied to Bone Mineral Density Post-Menopause<\/font><\/p>\n MONDAY, May 14, 2018 (HealthDay News) — Anxiety levels are associated with bone mineral density (BMD) and fracture risk in the lumbar spine and femoral neck among postmenopausal women, according to a study published online May 7 in Menopause<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Overall, Drinking Wine Does Not Impact Prostate Cancer Risk<\/font><\/p>\n MONDAY, May 14, 2018 (HealthDay News) — Moderate wine consumption does not seem to impact the risk of prostate cancer, according to a review published online April 17 in Clinical Epidemiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n CKAP4 Is Novel Serodiagnostic Marker for Lung Cancer<\/font><\/p>\n FRIDAY, May 11, 2018 (HealthDay News) — Cytoskeleton-associated protein 4 (CKAP4) appears to be a novel serodiagnostic marker for lung cancer, with increased levels in lung cancer patients versus healthy controls, according to a study published online May 8 in The American Journal of Pathology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Screening Blood Donations for Zika Virus Is Costly, Low Yield<\/font><\/p>\n FRIDAY, May 11, 2018 (HealthDay News) — Screening blood donations for Zika virus (ZIKV) in the United States is costly with low yield, according to a study published in the May 10 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n FDA Targets Clinics Offering Unapproved Stem Cell Therapies<\/font><\/p>\n THURSDAY, May 10, 2018 (HealthDay News) — The U.S. Food and Drug Administration has launched legal action to stop two stem cell clinics from providing unapproved treatments that have caused serious, long-term harm to some patients.<\/p>\n More Information<\/a><\/p>\n Novel Thirdhand Smoke Exposure Route Identified<\/font><\/p>\n THURSDAY, May 10, 2018 (HealthDay News) — Thirdhand smoke (THS), the chemical residue from cigarette smoke that attaches to anything and anyone in the vicinity of a smoke cloud, can still make its way into the air of buildings that currently have a non-smoking designation, according to a study published online May 9 in Science Advances<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Uveal Effusion Reported After Initiation of Anti-PD-1, -PD-L1<\/font><\/p>\n THURSDAY, May 10, 2018 (HealthDay News) — Patients receiving immunotherapy with antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies may develop uveal effusion, according to a report published online April 12 in JAMA Ophthalmology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Nodal Metastasis Risk Up When Cancer Is Directly on the Lip<\/font><\/p>\n THURSDAY, May 10, 2018 (HealthDay News) — The risk of nodal metastasis is five-fold greater for skin cancer on the vermilion lip versus the cutaneous lip, according to a study published online May 2 in JAMA Dermatology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Age of First Football Tackles Tied to Neuro Symptom Onset<\/font><\/p>\n THURSDAY, May 10, 2018 (HealthDay News) — Younger age of exposure to tackle football predicts earlier neurobehavioral symptom onset among players with chronic traumatic encephalopathy (CTE), according to a study published online April 30 in the Annals of Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Crowdfunding Exaggerates Efficacy of Unproven Stem Cell Tx<\/font><\/p>\n WEDNESDAY, May 9, 2018 (HealthDay News) — Crowdfunding campaigns for unproven stem cell-based interventions tend to exaggerate the efficacy and underemphasize the risks, according to a research letter published in the May 8 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Women Have Stronger Link Between APOE<\/i>-\u03b54, CSF Tau Levels<\/font><\/p>\n WEDNESDAY, May 9, 2018 (HealthDay News) — The correlation between the apolipoprotein E (APOE<\/i>) gene allele APOE<\/i>-\u03b54 and cerebrospinal fluid (CSF) tau levels is stronger among women than men, according to a study published online May 7 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Chronic Aspirin Exposure Linked to Melanoma Risk in Males<\/font><\/p>\n WEDNESDAY, May 9, 2018 (HealthDay News) — Chronic acetylsalicylic acid (ASA; aspirin) exposure is associated with increased risk of malignant melanoma (MM) in men, but not women, according to a letter to the editor published online March 27 in the Journal of the American Academy of Dermatology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n USPSTF: Decision to Undergo PSA Screening Should Be Individual<\/font><\/p>\n TUESDAY, May 8, 2018 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) concludes that the decision to undergo periodic prostate-specific antigen (PSA) screening for prostate cancer should be an individual one for men aged 55 to 69 years. These findings form the basis of a final recommendation statement, published in the May 8 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Evidence Report<\/a><\/p>\n Final Recommendation Statement<\/a><\/p>\n Editorial<\/a><\/p>\n Regulatory Requirements Drive Dissatisfaction With EHRs<\/font><\/p>\n TUESDAY, May 8, 2018 (HealthDay News) — Regulatory requirements are likely to be an important aspect of physician dissatisfaction with electronic health records (EHRs) that is driving burnout, according to an Ideas and Opinions piece published online May 8 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Long-Term Cardiovascular Risk for Endometrial Cancer Survivors<\/font><\/p>\n TUESDAY, May 8, 2018 (HealthDay News) — Endometrial cancer survivors have an elevated risk of various adverse long-term cardiovascular outcomes, according to a study published online May 8 in the Journal of the National Cancer Institute<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Automated Algorithm Accurately IDs Plus Disease in ROP<\/font><\/p>\n TUESDAY, May 8, 2018 (HealthDay News) — A fully automated algorithm can accurately diagnose plus disease in retinopathy of prematurity (ROP), according to a study published online May 2 in JAMA Ophthalmology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Folic Acid May Cut Stroke Risk in High-Risk Hypertensive Patients<\/font><\/p>\n MONDAY, May 7, 2018 (HealthDay News) — Hypertensive patients may lower their stroke risk with folic acid supplements, according to a study published in the May 15 issue of the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Eyes of Ebola Survivors Show Localized Pathological Changes<\/font><\/p>\n MONDAY, May 7, 2018 (HealthDay News) — Survivors of Ebola virus disease (EVD) have localized pathological changes in photoreceptors, according to a study published online May 3 in JAMA Ophthalmology<\/i>.<\/p>\n