{"id":60219,"date":"2021-08-12T00:00:00","date_gmt":"2021-08-12T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2021\/08\/12\/dpp-4i-use-may-protect-in-alzheimer-dementia-with-diabetes\/"},"modified":"2021-08-16T16:11:42","modified_gmt":"2021-08-16T16:11:42","slug":"dpp-4i-use-may-protect-in-alzheimer-dementia-with-diabetes","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2021\/08\/12\/dpp-4i-use-may-protect-in-alzheimer-dementia-with-diabetes\/","title":{"rendered":"DPP-4i Use May Protect in Alzheimer Dementia With Diabetes"},"content":{"rendered":"<h3>\n<p>Low amyloid burden and favorable cognitive outcomes seen with DPP-4i use in Alzheimer disease-related cognitive impairment with diabetes<\/p>\n<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>THURSDAY, Aug. 12, 2021 (HealthDay News) &#8212; For patients with Alzheimer disease-related cognitive impairment (ADCI) and diabetes, dipeptidyl peptidase-4 inhibitor (DPP-4i) use is associated with low amyloid burden and favorable cognitive outcomes, according to a study published online Aug. 11 in <em>Neurology<\/em>.<\/p>\n<p>Seong Ho Jeong, M.D., from Yonsei University College of Medicine in Seoul, South Korea, and colleagues conducted a retrospective review of 282 patients with ADCI who had a positive scan of <sup>18<\/sup>F-florbetaben amyloid positron emission tomography images. Patients were classified according to diabetes diagnosis and DPP-4i use: patients with diabetes treated with DPP-4i (ADCI-DPP-4i<sup>+<\/sup>; 70 patients), patients with diabetes without DPP-4i treatment (ADCI-DPP-4i<sup>\u00e2\u0088\u0092<\/sup>; 71 patients), and patients without diabetes (141 patients).<\/p>\n<p>The researchers found that after adjustment for age, sex, education, cognitive status, and <em>APOE<\/em> \u00ce\u00b54 carrier status, the ADCI-DPP-4i<sup>+<\/sup> group had lower global amyloid burden than the ADCI-DPP-4i<sup>\u00e2\u0088\u0092<\/sup> group or the group without diabetes ( \u009f = 0.075 and 0.054, respectively). In addition, compared with the ADCI-DPP-4i<sup>\u00e2\u0088\u0092<\/sup> group or the group without diabetes, the ADCI-DPP-4i<sup>+<\/sup> group had lower regional amyloid burden in temporo-parietal areas. A slower longitudinal decrease in Mini-Mental State Examination score and memory recall subscore was seen for the ADCI-DPP-4i<sup>+<\/sup> group compared with the ADCI-DPP-4i<sup>\u00e2\u0088\u0092<\/sup> group.<\/p>\n<p>&#8220;Not only did our study show that people taking dipeptidyl peptidase-4 inhibitors to lower blood sugar levels had less amyloid in their brains overall, it also showed lower levels in areas of the brain involved in Alzheimer&#8217;s disease,&#8221; a coauthor said in a statement.<\/p>\n<p><a href=\"https:\/\/n.neurology.org\/lookup\/doi\/10.1212\/WNL.0000000000012534\" target=\"_blank\" rel=\"noopener\">Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2021 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\" rel=\"noopener\">HealthDay<\/a>. All rights reserved.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Low amyloid burden and favorable cognitive outcomes seen with DPP-4i use in Alzheimer disease-related cognitive impairment with diabetes<\/p>\n","protected":false},"author":6,"featured_media":60454,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-60219","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/60219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=60219"}],"version-history":[{"count":0,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/60219\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/60454"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=60219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=60219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=60219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}