Regular versus poor antidepressant use tied to lower risk for advanced diabetic complications, mortality in patients with depression and diabetes<\/p>\n<\/h3>\n
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FRIDAY, July 23, 2021 (HealthDay News) — Regular antidepressant use is associated with a lower risk for diabetes complications among adults with depression and newly treated diabetes, according to a study published online July 14 in the Journal of Clinical Endocrinology & Metabolism<\/em>.<\/p>\n Chi-Shin Wu, M.D., Ph.D., from the National Taiwan University Hospital in Taipei, and colleagues examined the association between antidepressant treatment and advanced diabetic complications and mortality in a retrospective cohort study of 36,276 patients with depression and newly treated diabetes using the Taiwan universal health insurance database. Within a six-month window, antidepressant treatment patterns were classified into none, poor, partial, and regular use.<\/p>\n The researchers found that regular use of antidepressants was associated with a 0.92-fold reduced risk for macrovascular complications and with a 0.86-fold reduced risk for all-cause mortality compared with poor antidepressant use; no association was seen with microvascular complications. There were associations observed between regular use of selective serotonin reuptake inhibitors and a 0.83-fold and 0.75-fold reduced risk for macrovascular complications and all-cause mortality, respectively. The risk for all-cause mortality was reduced 0.78-fold in association with regular use of tricyclic or tetracyclic antidepressants. No association was seen for regular use of benzodiazepines with diabetes outcomes.<\/p>\n “Clinicians should emphasize antidepressant treatment adherence among patients with depression and diabetes mellitus,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n