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THURSDAY, May 24, 2018 (HealthDay News) — Each hour of delay in detecting abnormal lactates in patients with sepsis increases the odds of in-hospital death, according to a study published online May 24 in CHEST<\/i>.<\/p>\n
Xuan Han, M.D., from the University of Chicago, and colleagues evaluated the implications of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) on patient care and outcomes among adults admitted to a single institution between November 2008 and January 2016.<\/p>\n
The researchers found that lactates were measured within the mandated window 32 percent of the time on the ward (505 patients) compared with the intensive care unit (55 percent; 818 patients) and the emergency department (79 percent; 2,144 patients). The highest in-hospital mortality (29 percent) was seen in patients with delayed lactate measurements, which increased time to antibiotic administration. Increased odds of death were seen in patients with initial lactates >2.0 mmol\/L and hourly delay in lactate measurement (odds ratio, 1.02).<\/p>\n
“Systematic early lactate measurement for all patients with sepsis will lead to a significant increase in lactate draws that may prompt more rapid physician intervention for patients with abnormal initial values,” the authors write.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n