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WEDNESDAY, May 23, 2018 (HealthDay News) — Cinnamaldehyde, a commonly used flavoring agent in electronic cigarettes (e-cigarettes), disrupts mitochondrial function, correlating with impaired cilia beat frequency (CBF), according to a study presented at the American Thoracic Society’s 2018 International Conference, held from May 18 to 23 in San Diego.<\/p>\n
Phillip Clapp, Ph.D., from the University of North Carolina at Chapel Hill, and colleagues exposed well-differentiated human bronchial epithelial cell (HBEC) cultures to diluted cinnamon e-liquids and e-liquid aerosol generated by a third-generation e-cigarette device. Using a high-speed digital camera and the Sisson Ammons Video Analysis system, CBF was quantified over 120 minutes. HBECs were exposed to various concentration of cinnamaldehyde to establish a dose-response relationship for CBF alteration.<\/p>\n
The researchers found that cinnamaldehyde-containing e-liquid and e-liquid aerosol rapidly suppressed CBF, which lasted for about 60 minutes. The transient ciliostasis that was seen with exposure to e-liquid was recapitulated by exposure to cinnamaldehyde alone. There was impairment of mitochondrial oxidative phosphorylation in a dose-response manner with cinnamaldehyde; following exposure, intracellular adenosine triphosphate levels were reduced significantly. Cells exposed to cinnamaldehyde had cinnamaldehyde adducts with redox and energy metabolism proteins.<\/p>\n
“Our finding that cinnamaldehyde impairs normal airway cilia motility is significant because it demonstrates that a common, food-safe flavoring agent, in the context of e-cigarette use, is capable of dysregulating a critical anti-bacterial defense system in the lungs,” Clapp said in a statement.<\/p>\n
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