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WEDNESDAY, May 23, 2018 (HealthDay News) — There is an inverse association for plasma 25-hydroxyvitamin D (25[OH]D) concentration with diabetes risk, according to a study published online April 19 in PLOS ONE<\/i>.<\/p>\n
Sue K. Park, M.D., Ph.D., from the Seoul National University College of Medicine in South Korea, and colleagues performed a cohort study involving 903 adults who were known to be free of diabetes or prediabetes during a visit conducted in 1997 to 1999. Plasma 25(OH)D was measured, and fasting plasma glucose and oral glucose tolerance testing were conducted. Patients were followed through 2009.<\/p>\n
The researchers identified 47 cases of diabetes and 337 cases of prediabetes. There was a correlation for higher 25(OH)D concentrations (>30 ng\/mL) with lower hazard ratios for diabetes (hazard ratios, 0.31 for 30 to 39 ng\/mL, 0.29 for 40 to 49 ng\/mL, and 0.19 for >50 ng\/mL compared with <30 ng\/mL). An inverse dose-response gradient was seen between 25(OH)D concentration and risk of diabetes (P for trend 0.005). The hazard ratio was 0.64 in association with each 10 ng\/mL higher 25(OH)D concentration. There was a more weak inverse association for 25(OH)D concentrations with prediabetes risk; however, the trend was not significant.<\/p>\n
“Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes,” the authors write.<\/p>\n