Twenty-five percent experienced CVD event during follow-up; risk up for \u00df-blocker use but not with calcium channel blockers, diuretics<\/p>\n<\/h3>\n
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MONDAY, April 5, 2021 (HealthDay News) — For veterans with HIV and hypertension, the rate of cardiovascular disease (CVD) events is high and is increased in association with \u009f-blocker use, according to a study published online April 5 in Hypertension<\/em>.<\/p>\n Leah B. Rethy, M.D., from the University of Pennsylvania in Philadelphia, and colleagues used propensity matching to examine the risk of incident\/recurrent CVD or death, incident CVD, and incident heart failure by antihypertensive class among veterans with HIV and incident hypertension (2000 to 2018).<\/p>\n Of 8,041 veterans, 24, 23, 13, and 11 percent were initiated on angiotensin-converting enzyme (ACE) inhibitor\/angiotensin receptor blocker (ARB) monotherapy, thiazide\/thiazide-like diuretic monotherapy, \u009f-blocker monotherapy, and calcium channel blocker monotherapy, respectively. The researchers found that 25 percent experienced a CVD event over a median of 6.5 years. Increased risk of incident CVD was seen in association with \u009f-blockers but not calcium channel blockers or diuretics compared with ACE inhibitors\/ARBs (hazard ratio, 1.90 for \u009f-blockers); similar hazard ratios were seen for incident\/recurrent CVD or death. ACE inhibitors\/ARBs were associated with a lower risk of incident heart failure compared with all other classes among veterans without chronic kidney disease (hazard ratios, 1.52, 1.48, and 1.52 for \u009f-blockers, calcium channel blockers, and diuretics, respectively).<\/p>\n “Patients with HIV need heightened attention to their elevated risk of heart disease,” a coauthor said in a statement. “More dedicated research studying the unique needs for people with HIV and those taking antiretroviral therapies is needed in order to optimize cardiovascular prevention.”<\/p>\n One author disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n