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THURSDAY, May 10, 2018 (HealthDay News) — Patients receiving immunotherapy with antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies may develop uveal effusion, according to a report published online April 12 in JAMA Ophthalmology<\/i>.<\/p>\n
Merina Thomas, M.D., from the University of Michigan in Ann Arbor, and colleagues describe three patients who developed uveal effusion after initiation of anti-PD-1 and anti-PD-L1 monoclonal antibody therapy. The patients were two white men aged 52 and 85 years with metastatic cutaneous melanoma and a 68-year-old African-American man with metastatic adenocarcinoma of the lung. All three patients were receiving anti-PD-1 and anti-PD-L1 monoclonal antibody therapy.<\/p>\n
The researchers found that all three patients developed uveal effusion within one to two months after initiation of anti-PD-1 and anti-PD-L1 monoclonal antibody therapy. In six to 12 weeks after discontinuation of systemic therapy, uveal effusion resolved completed in two patients; uveal effusion persisted in one patient who continued therapy.<\/p>\n
“Uveal effusion should be considered in patients taking anti-PD-1 and\/or PD-L1 monoclonal antibody therapy,” the authors write. “Because of the role of the PD-1 pathway in the inhibition of self-reactive T cells, PD-1 inhibition might lead to inflammation because of immune-related adverse effects.”<\/p>\n
One author disclosed financial ties to Castle Biosciences.<\/p>\n
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