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THURSDAY, May 10, 2018 (HealthDay News) — A restrictive fluid regimen is not associated with increased disability-free survival for patients at increased risk of complications during major abdominal surgery, but is associated with increased acute kidney injury, according to a study published online May 10 in the New England Journal of Medicine<\/i>. The research was published to coincide with the annual meeting of the Australian and New Zealand College of Anaesthetists, held from May 7 to 11 in Sydney.<\/p>\n
Paul S. Myles, M.P.H., D.Sc., from Monash University in Melbourne, Australia, and colleagues randomized 3,000 patients who had an increased risk of complications while undergoing major abdominal surgery to receive a restrictive or liberal intravenous-fluid regimen during and up to 24 hours after surgery (1,490 and 1,493 patients, respectively).<\/p>\n
The researchers found that at one-year, the rate of disability-free survival was 81.9 and 82.3 percent in the restrictive and liberal fluid groups, respectively (hazard ratio for death or disability, 1.05; 95 percent confidence interval, 0.88 to 1.24; P = 0.61). The rate of acute kidney injury was 8.6 and 5.0 percent in the restrictive and liberal fluid groups, respectively (P < 0.001).<\/p>\n
“Among patients at increased risk for complications during major abdominal surgery, a restrictive fluid regimen was not associated with a higher rate of disability-free survival than a liberal fluid regimen and was associated with a higher rate of acute kidney injury,” the authors write.<\/p>\n
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