Treatment with EPA-DHA or vitamin D3<\/sub> supplement versus placebo results in no significant difference in incident atrial fibrillation over five years<\/p>\n<\/h3>\n <\/b><\/p>\n <\/b><\/p>\n THURSDAY, March 18, 2021 (HealthDay News) — Neither marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), nor vitamin D3<\/sub> are associated with a reduction in the risk for incident atrial fibrillation (AF), according to a study published in the March 16 issue of the Journal of the American Medical Association<\/em>.<\/p>\n Christine M. Albert, M.D., M.P.H., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the effects of long-term administration of supplementation with marine omega-3 fatty acids and vitamin D on incident AF in an ancillary 2 x 2 factorial randomized clinical trial involving 25,119 women and men aged 50 years or older. Participants were randomly assigned to EPA-DHA and vitamin D3<\/sub> (6,272 analyzed); EPA-DHA and placebo (6,270 analyzed); vitamin D3<\/sub> and placebo (6,281 analyzed); or two placebos (6,296 analyzed).<\/p>\n The researchers found that the primary end point of incident AF occurred in 3.6 percent of the study participants during a median of 5.3 years of treatment and follow-up. Incident AF events occurred in 3.7 and 3.4 percent of participants for the EPA-DHA versus placebo comparison (hazard ratio, 1.09; 95 percent confidence interval, 0.96 to 1.24; P = 0.19). Incident AF events occurred in 3.7 and 3.4 percent of participants for the vitamin D3<\/sub> versus placebo comparison (hazard ratio, 1.09; 95 percent confidence interval, 0.96 to 1.25; P = 0.19). No evidence was seen for an interaction between the two study agents (hazard ratio, 1.07; 95 percent confidence interval, 0.92 to 1.25; P = 0.39).<\/p>\n “The findings do not support the use of either agent for the primary prevention of incident AF,” the authors write.<\/p>\n Pharmavite LLC provided the vitamin D\/placebo for the trial, and Quest Diagnostics performed the serum 25-hydroxyvitamin D and plasma phospholipid omega-3 measurements. Pronova BioPharma\/BASF donated omega-3 fatty acids.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n