Patients with scleritis have increased risk for prior diagnosis of infectious\/immune-mediated inflammatory disease<\/p>\n<\/h3>\n
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WEDNESDAY, March 17, 2021 (HealthDay News) — From 1997 to 2018, there was a decrease in the incidence of scleritis in the United Kingdom, according to a study published online March 16 in Arthritis & Rheumatology<\/em>.<\/p>\n Tasanee Braithwaite, D.M., from King’s College London, and colleagues estimated trends in scleritis prevalence and incidence in a retrospective cross-sectional and population cohort study from 1997 to 2018 involving 10,939,823 patients (2,946 incident scleritis cases) and from a case-control and cohort study from 1995 to 2019, which included 3,005 incident scleritis cases and 12,020 control patients.<\/p>\n The researchers found that between 1997 and 2018, the incidence rates of scleritis decreased from 4.23 to 2.79 per 100,000 person-years. In 2018, prevalence was 93.62 per 100,000 people. The risk for incident scleritis was increased in association with female sex (adjusted incidence rate ratio, 1.54), Black or South Asian race\/ethnicity versus White (adjusted incidence rate ratios, 1.52 and 1.50, respectively), and older age (peak adjusted incidence rate ratio, 4.95 for ages 51 to 60 years versus <10 years). Patients with scleritis had a twofold increased risk for a prior diagnosis of infectious\/immune-mediated inflammatory disease (I-IMID) compared with controls, as well as a significantly increased risk for a subsequent diagnosis of 13 I-IMIDs. The most strongly associated I-IMIDs were granulomatosis with polyangiitis, Beh \u00a7et disease, and Sj \u00b6gren syndrome.<\/p>\n “The interplay between ophthalmologically managed scleritis, and I-IMIDs managed by rheumatology and other specialties, highlights the need for multispecialty care pathways for patients with this potentially blinding disease,” the authors write.<\/p>\n One author disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n