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WEDNESDAY, May 9, 2018 (HealthDay News) — Chronic acetylsalicylic acid (ASA; aspirin) exposure is associated with increased risk of malignant melanoma (MM) in men, but not women, according to a letter to the editor published online March 27 in the Journal of the American Academy of Dermatology<\/i>.<\/p>\n
Kelsey A. Orrell, M.B., B.Ch., from Northwestern University Feinberg School of Medicine in Chicago, and colleagues reviewed a single-center medical record data repository to examine the risk of MM after chronic aspirin exposure. All patients aged 18 to 89 years with no prior history of MM and a minimum follow-up of five years after continuous once-daily ASA exposure for one year or more were included. All patients within the same time frame with no documented ASA exposure were included as controls.<\/p>\n
The researchers observed a significant correlation between ASA exposure and subsequent diagnosis of MM (adjusted relative risk, 1.48; 95 percent confidence interval, 1.01 to 2.18; P = 0.046). After stratification by gender, a significant correlation was seen for males (adjusted relative risk, 1.83; 95 percent confidence interval, 1.22 to 2.76; P = 0.004), but not females (adjusted relative risk, 0.53; 95 percent confidence interval, 0.17 to 1.63; P = 0.266). There was no evidence of a dose-response relationship.<\/p>\n
“Although the mechanism for these findings is unclear, given the potential clinical impact, further exploration of the risk related to chronic, once-daily aspirin exposure and subsequent diagnosis of melanoma is warranted,” the authors write.<\/p>\n
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