Findings based on systematic review and meta-analysis of pooled data from 12 studies involving more than 1.85 million participants<\/p>\n<\/h3>\n
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MONDAY, March 1, 2021 (HealthDay News) — A childhood diagnosis of attention-deficit\/hyperactivity disorder (ADHD) is associated with an increased risk for a subsequent psychotic disorder, according to a review published online Feb. 24 in JAMA Psychiatry<\/em>.<\/p>\n Mika \u00afl Nourredine, M.D., from Hospices Civils de Lyon in France, and colleagues conducted a systematic literature review to identify studies exploring the association between ADHD (diagnosed before 18 years of age) and the risk for subsequent psychotic disorder.<\/p>\n Based on 12 pooled studies (1.85 million participants), the researchers found that a diagnosis of ADHD in childhood was associated with a significant increase in the risk for subsequent psychotic disorder, with a pooled relative effect of 4.74. There were no significant between-group differences observed in subgroup analyses based on psychotic disorder (odds ratio [OR], 5.04) or schizophrenia (OR, 4.59) outcomes. Results were similar by study design (cohort: OR, 4.64; case-control: OR, 6.81), as well as in adjusted (OR, 4.72) and unadjusted (OR, 3.81) analyses.<\/p>\n “Further studies are required to determine the mechanisms linking these common conditions and whether early intervention for ADHD might reduce the risk of subsequent psychotic disorder,” the authors write.<\/p>\n