No significant differences seen for other outcomes among patients hospitalized with moderate-to-severe disease<\/p>\n<\/h3>\n
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MONDAY, March 1, 2021 (HealthDay News) — A single high dose of vitamin D3<\/sub> does not shorten length of stay or improve other outcomes among patients hospitalized for COVID-19, according to a study published online Feb. 17 in the Journal of the American Medical Association<\/em>.<\/p>\n Igor H. Murai, Ph.D., from the University of Sao Paulo in Brazil, and colleagues randomly assigned hospitalized patients with moderate-to-severe COVID-19 (June 2 to August 27, 2020) to receive a single oral dose of 200,000 IU of vitamin D3<\/sub> (120 patients) or placebo (120 patients).<\/p>\n The researchers found that the median length of stay was not significantly different between the vitamin D3<\/sub> and placebo groups (seven days for both; unadjusted hazard ratio for hospital discharge, 1.07; 95 percent confidence interval [CI], 0.82 to 1.39; P = 0.62). The groups were also similar with respect to in-hospital mortality (7.6 versus 5.1 percent; difference, 2.5 percent; 95 percent CI, \u00e2\u0080\u00934.1 to 9.2 percent; P = 0.43), admission to the intensive care unit (16.0 versus 21.2 percent; difference, \u00e2\u0080\u00935.2 percent; 95 percent CI, \u00e2\u0080\u009315.1 to 4.7 percent; P = 0.30), and need for mechanical ventilation (7.6 versus 14.4 percent; difference, \u00e2\u0080\u00936.8 percent; 95 percent CI, \u00e2\u0080\u009315.1 to 1.2 percent; P = 0.09). There were increases observed in the mean serum levels of 25-hydroxyvitamin D after the single dose of vitamin D3<\/sub> versus placebo (44.4 versus 19.8 ng\/mL; difference, 24.1 ng\/mL; 95 percent CI, 19.5 to 28.7; P < 0.001). No adverse events were reported, although there was an episode of vomiting associated with the intervention.<\/p>\n “The findings do not support the use of a high dose of vitamin D3<\/sub> for treatment of moderate-to-severe COVID-19,” the authors write.<\/p>\n Abstract\/Full Text<\/a><\/p>\n