Exercise training, but not testosterone, improves endothelium-dependent vascular function in men with low-normal testosterone <\/p>\n<\/h3>\n
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MONDAY, Feb. 22, 2021 (HealthDay News) — For men with low-normal serum testosterone levels, exercise training improves endothelium-dependent vascular function, but testosterone administration does not, according to a study published online Feb. 22 in Hypertension.<\/em><\/p>\n Lauren C. Chasland, from The University of Western Australia in Perth, and colleagues compared the impacts of testosterone and exercise training, alone and in combination, on endothelium-dependent flow-mediated dilation percentage and endothelium-independent glyceryl trinitrate percentage responses in a 12-week trial. Eighty men aged 50 to 70 years with low-normal serum testosterone levels and waist circumference \u00e2\u0089\u00a595 cm were randomly assigned to either testosterone (transdermal) or matching placebo and to either supervised center-based exercise or no exercise.<\/p>\n The researchers found that serum testosterone levels were increased with testosterone, with 62 percent of subjects in the testosterone group having levels >14 nmol\/L; no impact on testosterone levels was seen for placebo treatment. Increased flow-mediated dilation percentage was seen with exercise training, while testosterone had no impact on flow-mediated dilation, nor was it additive to exercise. No significant exercise or drug main effects were seen on glyceryl trinitrate responses.<\/p>\n “While we conclude that exercise improves vascular function in middle-to-older aged men with low-normal testosterone levels, caution should be applied when prescribing testosterone if the primary aim is improvement in artery function and health,” the authors write.<\/p>\n One author disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n