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Here are what the editors at HealthDay consider to be the most important developments in Pathology for April 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.<\/p>\n
Review: Need to Strengthen Natural Experiments in Obesity<\/font><\/p>\n MONDAY, April 30, 2018 (HealthDay News) — Based on findings from a systematic review of the literature, recommendations have been developed for improving the evidence for natural experiments in obesity; the review and position paper were published online May 1 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text – Review (subscription or payment may be required)<\/a><\/p>\n Abstract\/Full Text – Position Paper (subscription or payment may be required)<\/a><\/p>\n Similar Risk Predicted for Automated, Clinical BI-RADS Density<\/font><\/p>\n MONDAY, April 30, 2018 (HealthDay News) — Automated and clinical Breast Imaging Reporting and Data System (BI-RADS) density measures similarly predict breast cancer risk, according to a study published online May 1 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Five Healthy Lifestyle Habits Could Add >10 Years to Life<\/font><\/p>\n MONDAY, April 30, 2018 (HealthDay News) — Adopting a healthy lifestyle, with five low-risk lifestyle factors is associated with increased life expectancy, according to a study published online April 30 in Circulation<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Liver-Kidney Recipients Have Donor-Specific Hypo-Responses<\/font><\/p>\n MONDAY, April 30, 2018 (HealthDay News) — Simultaneous liver-kidney transplant recipients’ peripheral blood cells have unique phenotypic and functional characteristics that are associated with donor-specific hypo-alloresponsiveness, according to a study published online April 12 in Kidney International<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n CCHD Newborn Screening May Detect Other Diseases<\/font><\/p>\n MONDAY, April 30, 2018 (HealthDay News) — Critical congenital heart disease (CCHD) newborn screening detects a low percentage of new cases of CCHD, but it can detect other important diseases, according to a study published online April 24 in Pediatrics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n ALS by Physician May Improve Traumatic Arrest Outcomes<\/font><\/p>\n FRIDAY, April 27, 2018 (HealthDay News) — For patients with traumatic out-of-hospital cardiac arrest (OHCA), pre-hospital advanced life support (ALS) provided by a physician is associated with increased likelihood of one-month survival, according to a study published online April 25 in JAMA Surgery<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Spermatogenesis Still Occurs in Men With Testicular Cancer<\/font><\/p>\n FRIDAY, April 27, 2018 (HealthDay News) — Spermatogenesis occurs in most men with testicular cancer, often away from tumors, according to a study published online April 17 in BJU International<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Sickle Cell Trait Not Linked to Stroke in African-Americans<\/font><\/p>\n FRIDAY, April 27, 2018 (HealthDay News) — For African-Americans, sickle cell trait (SCT) seems not to be associated with the incidence of ischemic stroke, according to a meta-analysis published online April 23 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Improvement in Race-Based Disparities in Years of Life Lost<\/font><\/p>\n THURSDAY, April 26, 2018 (HealthDay News) — From 1990 to 2014 there was a decrease in race-based disparities in years of life lost (YLL) in the United States, according to a study published online April 25 in PLOS ONE<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Multiple Myeloma Risk May Be Up for WTC-Exposed Firefighters <\/font><\/p>\n THURSDAY, April 26, 2018 (HealthDay News) — World Trade Center-exposed firefighters have increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and light-chain MGUS, which are precursors to multiple myeloma, as well as an increased cancer burden, according to two studies published online April 26 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text – Landgren<\/a><\/p>\n Abstract\/Full Text – Singh<\/a><\/p>\n Editorial<\/a><\/p>\n Fetal Inflammation May Play Role in Preterm Labor<\/font><\/p>\n WEDNESDAY, April 25, 2018 (HealthDay News) — Fetal inflammation and rejection of maternal antigens is associated with uterine contractility and aberrant fetal immune responses, which may play a role in preterm labor (PTL), according to a study published in the April 25 issue of Science Translational Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Medicare Requiring Hospitals to Post Prices Online<\/font><\/p>\n WEDNESDAY, April 25, 2018 (HealthDay News) — U.S. hospitals will have to post their standard prices online and make it easier for patients to access their electronic medical records, Medicare officials said Tuesday.<\/p>\n More Information<\/a><\/p>\n IBD Associated With Increased Incidence of Parkinson’s Disease<\/font><\/p>\n WEDNESDAY, April 25, 2018 (HealthDay News) — Patients with inflammatory bowel disease (IBD) have increased incidence of Parkinson’s disease (PD), which is attenuated with anti-tumor necrosis factor (TNF) therapy, according to a study published online April 23 in JAMA Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Increase in HTN in Children Based on 2017 AAP Guidelines<\/font><\/p>\n WEDNESDAY, April 25, 2018 (HealthDay News) — The prevalence and severity of high blood pressure (BP) in children have increased based on the 2017 American Academy of Pediatrics clinical practice guidelines, according to a study published online April 23 in JAMA Pediatrics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Aortic Stiffness, Concentric LV Remodeling Linked in T2DM<\/font><\/p>\n WEDNESDAY, April 25, 2018 (HealthDay News) — For patients with type 2 diabetes, aortic stiffness is associated with concentric left ventricular (LV) remodeling, according to a study published online April 16 in Diabetes<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Preteens Metabolically Comparable to Trained Athletes<\/font><\/p>\n TUESDAY, April 24, 2018 (HealthDay News) — Prepubertal children are metabolically comparable to adult endurance athletes, and less fatiguable with high intensity exercise than untrained adults, according to a study published online April 24 in the Frontiers in Physiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis<\/font><\/p>\n TUESDAY, April 24, 2018 (HealthDay News) — There is a linear correlation for physical activity (PA) with amyotrophic lateral sclerosis (ALS), according to a study published online April 23 in the Journal of Neurology, Neurosurgery & Psychiatry<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Alcohol Intake May Influence Oral Microbiome Composition<\/font><\/p>\n TUESDAY, April 24, 2018 (HealthDay News) — Alcohol consumption, specifically heavy drinking, may influence the oral microbiome composition, according to a study published online April 24 in Microbiome<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Black Men More Likely to Die From Firearm Homicide<\/font><\/p>\n TUESDAY, April 24, 2018 (HealthDay News) — Firearm homicides are much more common among black men compared to white men, particularly in rust belt states, according to a study published online April 24 in the Annals of Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Factors ID’d to Predict Fatty Liver in Obese Teens<\/font><\/p>\n MONDAY, April 23, 2018 (HealthDay News) — Ethnicity\/race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver, according to a study published online April 17 in Hepatology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Cancer Screening More Likely After a Previous False Positive<\/font><\/p>\n MONDAY, April 23, 2018 (HealthDay News) — Patients who previously had a false-positive breast or prostate cancer screening test result are more likely to have future screenings, according to a study published online April 23 in Cancer<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Grip Strength Indicative of Cognition in Major Depression<\/font><\/p>\n MONDAY, April 23, 2018 (HealthDay News) — For individuals with major depression and bipolar disorder, grip strength is positively associated with cognition, according to a study published online April 18 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Questions Surround Concept of Internet Gaming Disorder<\/font><\/p>\n FRIDAY, April 20, 2018 (HealthDay News) — The concept of internet gaming disorder (IGD) and the pathways leading to it are unclear, according to a review published online April 6 in Developmental Medicine & Child Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n High FGF-23 Linked to Recurrent Cardiac Events After ACS<\/font><\/p>\n FRIDAY, April 20, 2018 (HealthDay News) — Elevated fibroblast growth factor 23 (FGF-23) is associated with increased risk of recurrent major cardiovascular (CV) events in patients after an acute coronary syndrome (ACS), according to a study published online April 18 in JAMA Cardiology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Annual Visits May Not Increase Cognitive Impairment Detection<\/font><\/p>\n FRIDAY, April 20, 2018 (HealthDay News) — Medicare Annual Wellness Visits (AWVs) do not appear to substantially increase the detection of cognitive impairment in older adults, according to a study published online April 2 in the Journal of the American Geriatrics Society<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n In LVSD, Diabetes Tied to Higher Risk of Heart Failure<\/font><\/p>\n FRIDAY, April 20, 2018 (HealthDay News) — In patients with asymptomatic left ventricular systolic dysfunction, diabetes is associated with an increased risk of developing heart failure, according to a study published online April 6 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Gene Therapy Found to Be Promising for \u03b2-Thalassemia<\/font><\/p>\n THURSDAY, April 19, 2018 (HealthDay News) — For patients with severe \u03b2-thalassemia, the need for red-cell transfusions can be reduced or eliminated by transducing cells with the LentiGlobin BB305 vector, according to a study published in the April 18 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Cellular Biomedical Tattoo Can ID Hypercalcemia-Linked Cancer<\/font><\/p>\n WEDNESDAY, April 18, 2018 (HealthDay News) — A cell-based biomedical tattoo can detect hypercalcemia associated with cancer in a murine model, according to an experimental study published in the April 18 issue of Science Translational Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Mild TBI May Increase Risk of Parkinson’s Disease<\/font><\/p>\n WEDNESDAY, April 18, 2018 (HealthDay News) — Mild traumatic brain injury (TBI) is associated with increased risk of Parkinson’s disease (PD) among military veterans, according to a study published online April 18 in Neurology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Young Adults With T1DM Show Muscle Metabolic Deficiencies<\/font><\/p>\n WEDNESDAY, April 18, 2018 (HealthDay News) — Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle, according to a study published online April 18 in Diabetologia<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Males With BRCA<\/i> Mutations Have Increased Risk of Certain Cancers<\/font><\/p>\n TUESDAY, April 17, 2018 (HealthDay News) — Males with BRCA<\/i> mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers, according to a research letter published online April 12 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Recommendations Developed on Gender Equity in Medicine<\/font><\/p>\n MONDAY, April 16, 2018 (HealthDay News) — In a position paper published online April 17 in the Annals of Internal Medicine<\/i>, recommendations are provided aimed at addressing gender equity in physician compensation and career advancement opportunities.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n TFs Operate Across Gene Loci Within Disease Phenotypes<\/font><\/p>\n MONDAY, April 16, 2018 (HealthDay News) — Transcription factors (TFs) seem to operate across gene loci, according to a study published online April 16 in Nature Genetics<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Increased Pollution Exposure Ups Health Care Visits for Acute URI<\/font><\/p>\n MONDAY, April 16, 2018 (HealthDay News) — Short-term exposure to fine particulate matter (PM2.5<\/sub>) is associated with increased health care utilization for acute lower respiratory infection (ALRI), according to a study published online April 13 in the American Journal of Respiratory and Critical Care Medicine<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Volumetric Laser Endomicroscopy Helps ID Barrett’s Regions<\/font><\/p>\n MONDAY, April 16, 2018 (HealthDay News) — Volumetric laser endomicroscopy (VLE) users can identify regions of interest for potential Barrett’s esophagus (BE) dysplasia with a high degree of agreement, according to a study published online April 6 in the Journal of Gastroenterology and Hepatology<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Nonoptimized Drug Therapy Costs More Than $500 Billion Annually<\/font><\/p>\n MONDAY, April 16, 2018 (HealthDay News) — The estimated annual cost of drug-related morbidity and mortality resulting from nonoptimized medication therapy is more than half a trillion dollars in the United States, according to a study published online March 26 in the Annals of Pharmacotherapy<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy<\/font><\/p>\n MONDAY, April 16, 2018 (HealthDay News) — One- and two-hour plasma glucose concentrations (1h-PG and 2h-PG, respectively) are similarly effective at predicting diabetic retinopathy (DR), according to a study published online April 5 in Diabetes Care<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Negative Affect That Lingers Tied to Health 10 Years Later<\/font><\/p>\n FRIDAY, April 13, 2018 (HealthDay News) — Negative affect that lingers is associated with worse physical health outcomes almost 10 years later, according to a study published online March 19 in Psychological Science<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Negative Fateful Life Events Linked to Advanced Brain Aging<\/font><\/p>\n THURSDAY, April 12, 2018 (HealthDay News) — Negative fateful life events (FLEs) in midlife are associated with advanced predicted brain aging, according to a study published in the July issue of Neurobiology of Aging<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Recent Years Saw Increase in Burden of Prior Authorization<\/font><\/p>\n THURSDAY, April 12, 2018 (HealthDay News) — The burden of prior authorization (PA) has increased over the past five years, and 92 percent of physicians report associated delays in access to care, according to the results of a survey published by the American Medical Association (AMA).<\/p>\n Abstract\/Full Text<\/a><\/p>\n Quality of Life Predicts Mortality in Older Breast Cancer Patients<\/font><\/p>\n THURSDAY, April 12, 2018 (HealthDay News) — For older women with early-stage breast cancer, measures of health-related quality of life (HRQOL) predict 10-year mortality independently of traditional breast cancer prognostic variables, according to a study published online March 13 in the Journal of the American Geriatrics Society<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Higher Mortality Risk Seen for ‘Night Owls’<\/font><\/p>\n THURSDAY, April 12, 2018 (HealthDay News) — Individuals with a later chronotype have increased mortality risk, according to a study published online April 12 in Chronobiology International<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n ZIKV RNA Often ID’d in Semen of Men With Symptomatic Infection<\/font><\/p>\n WEDNESDAY, April 11, 2018 (HealthDay News) — Zika virus (ZIKV) RNA is frequently present in the semen of men with symptomatic ZIKV infection and can persist for over six months, according to a study published in the April 12 issue of the New England Journal of Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial<\/a><\/p>\n Metabolic Syndrome Common in Patients With Lupus<\/font><\/p>\n TUESDAY, April 10, 2018 (HealthDay News) — As with the general population, metabolic syndrome (MetS) is common among patients with systemic lupus erythematosus (SLE), according to a study published online April 3 in the International Journal of Rheumatic Diseases<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Suggestions Offered to Reduce Physician Frustration With EHRs<\/font><\/p>\n TUESDAY, April 10, 2018 (HealthDay News) — Changes can be implemented to help reduce physician frustration with electronic health records (EHRs), according to an article published in Medical Economics<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Considerable Differences in Burden of Disease at State Level<\/font><\/p>\n TUESDAY, April 10, 2018 (HealthDay News) — There are considerable differences in the burden of disease at the state level, according to a study published in the April 10 issue of the Journal of the American Medical Association<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n One Night of Sleep Deprivation Linked to Amyloid-\u03b2 Burden<\/font><\/p>\n TUESDAY, April 10, 2018 (HealthDay News) — One night of sleep deprivation is associated with amyloid-\u03b2 (A\u03b2) burden (ABB) in healthy controls, according to a study published online April 9 in the Proceedings of the National Academy of Sciences<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Exercise Best Defense for Those at Genetic Risk for CVD<\/font><\/p>\n TUESDAY, April 10, 2018 (HealthDay News) — Fitness and physical activity are tied to lower risk of incident cardiovascular disease in the general population and among individuals with elevated genetic risk for cardiovascular diseases, according to a study published online April 9 in Circulation<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n White Matter Tracts Differ for Infants With Fragile X Syndrome<\/font><\/p>\n MONDAY, April 9, 2018 (HealthDay News) — There are significant differences in the development of 12 fiber tracts between infants with fragile X syndrome (FXS) and controls, according to a study published online April 4 in JAMA Psychiatry<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Interns’ Schedule Takes Toll on Sleep, Physical Activity, Mood<\/font><\/p>\n FRIDAY, April 6, 2018 (HealthDay News) — New interns’ intense and changing schedules take a toll on sleep, activity, and mood, according to a study published online March 14 in the Journal of General Internal Medicine<\/i>.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors<\/font><\/p>\n FRIDAY, April 6, 2018 (HealthDay News) — Myocarditis in patients treated with immune checkpoint inhibitors (ICIs) may be more common than previously thought, according to a study published online March 19 in the Journal of the American College of Cardiology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n Leukemia, and Its Treatment, May Pose Neurocognitive Risks<\/font><\/p>\n FRIDAY, April 6, 2018 (HealthDay News) — Underlying leukemia, even before chemotherapy, may pose a neurocognitive risk to young patients, according to a study published online March 29 in JAMA Oncology<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Glycemic Extremes in T1DM Impact Cognitive Skills in Kids<\/font><\/p>\n FRIDAY, April 6, 2018 (HealthDay News) — Type 1 diabetes is associated with cognitive dysfunction in children, according to a review published online March 23 in the Journal of Diabetes Investigation<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n ACA Marketplaces Expand Coverage for Chronically Ill<\/font><\/p>\n THURSDAY, April 5, 2018 (HealthDay News) — The Affordable Care Act’s Marketplaces covered a disproportionate share of non-elderly adults with high health care risks in the 2014 to 2015 time period, according to a study published in the April issue of Health Affairs<\/i>.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Preserved Neurogenesis in Hippocampus of Healthy Seniors<\/font><\/p>\n THURSDAY, April 5, 2018 (HealthDay News) — Healthy older subjects display preserved neurogenesis, according to a study published in the April 5 issue of Cell Stem Cell<\/i>.<\/p>\n