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MONDAY, April 30, 2018 (HealthDay News) — Simultaneous liver-kidney transplant recipients’ peripheral blood cells have unique phenotypic and functional characteristics that are associated with donor-specific hypo-alloresponsiveness, according to a study published online April 12 in Kidney International<\/i>.<\/p>\n
Timucin Taner, M.D., Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues measured donor-specific alloresponsiveness and phenotypes of peripheral blood cells after the first year to characterize the host alloimmune response in 28 patients who underwent simultaneous liver-kidney transplantation. Values were compared with those of 61 similarly immunosuppressed solitary kidney recipients or 31 liver allograft recipients.<\/p>\n
The researchers found that, compared with solitary kidney transplant recipients, simultaneous liver-kidney transplant recipients had lower overall frequency of circulating CD8+, activated CD4+, and effector memory T cells despite a significant overlap. Also compared with solitary kidney recipients, simultaneous liver-kidney transplant recipient T cells had a significantly lower proliferative response to the donor cells (11.9 versus 42.9 percent); their response to third-party cells was unchanged. Simultaneous liver-kidney transplant recipients had significantly lower frequency of interferon-gamma-producing alloreactive T cells than solitary kidney transplant recipients. Simultaneous liver-kidney transplant recipient circulating blood cells had smaller alloreactive CD4+ and CD8+ compartments.<\/p>\n
“The phenotypic and functional characteristics of the circulating blood cells of the simultaneous liver-kidney transplant recipients resembled those of solitary liver transplant recipients, and appear to be associated with donor-specific hypo-alloresponsiveness,” the authors write.<\/p>\n
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