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MONDAY, April 30, 2018 (HealthDay News) — Critical congenital heart disease (CCHD) newborn screening detects a low percentage of new cases of CCHD, but it can detect other important diseases, according to a study published online April 24 in Pediatrics<\/i>.<\/p>\n
Christina L. Diller, M.D., from Emory University in Atlanta, and colleagues retrospectively reviewed screening results from 77,148 term newborns without a known CCHD diagnosis at a tertiary birth hospital. The infants were screened using the American Academy of Pediatrics CCHD newborn screening algorithm. In addition, the authors modeled the results of a modified screening algorithm that used a single repeat pulse oximetry test instead of two.<\/p>\n
The researchers found that using the current AAP algorithm, 99.96 percent of infants passed screening. Of the infants who failed, 18 had an initial saturation of <90 percent and 16 did not attain a passing pulse oximetry level after three tests. Evaluation showed one true-positive (total anomalous pulmonary venous return), 33 false-positives -- of which 31.3 percent had significant non-CCHD disease -- and six false-negatives, yielding an overall specificity of 99.96 percent, a sensitivity of 14.3 percent, and a false-positive rate of 0.043 percent. The modified algorithm also had a sensitivity of 14.3 percent, but the false-positive rate increased to 0.054 percent.<\/p>\n
“Although CCHD screening in a tertiary care birth hospital may not detect many new cases of CCHD, it can detect other important diseases in newborns,” the authors write.<\/p>\n
One author disclosed financial ties to Novartis.<\/p>\n
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