Adenocarcinomas increasing in most early-onset subgroups; carcinoid tumors increasing more steeply in all age groups<\/p>\n<\/h3>\n
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MONDAY, Dec. 21, 2020 (HealthDay News) — Among individuals with early-onset colorectal cancer (EOCRC), adenocarcinoma rates are increasing in specific subgroups, but carcinoid tumors are increasing more steeply in all age groups, according to a study published online Dec. 15 in the Annals of Internal Medicine<\/em>.<\/em><\/p>\n Eric M. Montminy, M.D., from the Tulane University School of Medicine in New Orleans, and colleagues examined the incidence rates (IRs) of EOCRC and changes in IR over time in a retrospective analysis using Surveillance, Epidemiology, and End Results 18 data from 2000 to 2016 for 119,624 patients with CRC.<\/p>\n The researchers found that the steepest changes in adenocarcinoma three-year moving average IRs were seen for rectal-only cases in those aged 20 to 29 and 30 to 39 years and colon-only cases in those aged 30 to 39 years (+39, +39, and +20 percent, respectively), corresponding to annual percent changes of 1.6, 2.2, and 1.2 percent, respectively. The three-year moving average IRs increased in colon-only and rectal-only subsites among those aged 40 to 49 years (+13 and +16 percent, respectively). Carcinoid tumors were common and accounted for 4 to 20 percent of colorectal cancer cases and 8 to 34 percent of rectal cancer cases. Colon-only carcinoid tumors were rarely observed. In all age groups, colorectal carcinoid tumor IRs increased more steeply than adenocarcinomas.<\/p>\n “These findings underscore the importance of assessing histologic CRC subtypes independently,” the authors write. “This approach may lead to a better understanding of the drivers of temporal changes in overall CRC incidence.”<\/p>\n Two authors disclosed financial ties to Exact Sciences, a molecular diagnostics company.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n