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FRIDAY, April 20, 2018 (HealthDay News) — Eight factors contribute to postoperative pain after spine surgery, according to a study presented at the 2018 World Congress on Regional Anesthesia and Pain Medicine, held from April 19 to 21 in New York City.<\/p>\n
Quentin Baca, M.D., from Stanford University in California, and colleagues developed a model of postoperative pain after spine surgery. A total of 1,008 patients who underwent spine surgery under general anesthesia from 2011 to 2013 were included. An elastic net algorithm was used to create a predictive model of postoperative pain in the first 24 hours after surgery using a randomly selected training cohort; model performance was validated in an independent patient cohort, and bootstrap modeling of factor selection was used to characterize its stability.<\/p>\n
The researchers generated a cross-validated predictive model of postoperative pain. Bootstrap modeling of factor selection identified eight robust predictive factors: sex, preoperative pain, duration of surgery, remifentanil use, ketamine use, non-opioid intraoperative pain medication use, volatile anesthetic use, and post anesthesia care unit morphine equivalent consumption. These factors independently contributed to postoperative pain, and there was significant inter-dependence between several factors. There was a strong dependence of postoperative pain on the number of classes of non-opioid analgesics used during surgery and the use of intraoperative remifentanil.<\/p>\n
“The factors identified in this model and their relative contribution to postoperative pain present opportunities for interventions to improve pain control in the future,” the authors write.<\/p>\n