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TUESDAY, Sept. 8, 2020 (HealthDay News) — For patients with diabetes, coronary artery calcium (CAC) predicts cardiovascular disease (CVD) and total mortality more strongly in women than men, according to a study published online Aug. 17 in Diabetes Care<\/i>.<\/p>\n
Nathan D. Wong, Ph.D., from the University of California at Irvine, and colleagues used data from 4,503 adults (32.5 percent women; aged 21 to 93 years) with diabetes from a large registry of patients with CAC scanning and mortality follow-up over 11.5 years.<\/p>\n
The researchers found that total, CVD, and coronary heart disease (CHD) mortality rates were directly related to CAC. For CAC >100, women had higher total and CVD death rates than men. Per log unit CAC, age- and risk factor-adjusted total mortality and CVD mortality were higher among women versus men (hazard ratios [HRs], 1.28 versus 1.18 and 1.47 versus 1.27, respectively). However, CHD mortality rates were similar for men and women (HRs, 1.53 and 1.48, respectively). For CAC scores of 101 to 400 and >400, CVD mortality remained higher for women (HRs for women: 3.67 and 6.27, respectively; HRs for men: 1.63 and 3.48, respectively); the HRs for total mortality were 2.56 and 4.05, respectively, for women and 1.88 and 2.66, respectively, for men.<\/p>\n
“Given that awareness about extent of CVD in women remains underappreciated, our study contributes to increasing the importance of the clinician-patient risk discussion regarding risk factor modification efforts aimed to optimize the prevention of CVD events in women with diabetes,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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