<\/b><\/p>\n
<\/b><\/p>\n
FRIDAY, Aug. 21, 2020 (HealthDay News) — Single-dose targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy is an effective alternative to external beam radiotherapy (EBRT), according to a study published online Aug. 19 in The BMJ<\/i>.<\/p>\n
Jayant S. Vaidya, M.B.B.S., Ph.D., from University College London, and colleagues conducted a randomized trial in 32 centers in 10 countries involving 2,298 women aged 45 years and older with invasive ductal carcinoma up to 3.5 cm in size, stage cN0-N1, who were eligible for breast conservation. Participants were randomly assigned before lumpectomy to either risk-adapted TARGIT-IORT (1,140 patients) or EBRT (1,158 patients).<\/p>\n
The researchers found that TARGIT-IORT was noninferior to EBRT, with a local recurrence risk at five-year follow-up of 2.11 and 0.95 percent, respectively. For TARGIT-IORT versus EBRT, 13 additional local recurrences were reported as well as 14 fewer deaths in the first five years. No statistically significant difference was found for local recurrence-free survival, mastectomy-free survival, distant disease-free survival, overall survival, and breast cancer mortality with long-term follow-up (median, 8.6 years). Significantly lower mortality from other causes was observed.<\/p>\n
“We believe that the long term data presented in this paper, together with many benefits for the patient, provide compelling evidence in favor of TARGIT-IORT as an effective alternative for this large group of patients with early breast cancer who are suitable for breast conservation,” the authors write.<\/p>\n
Several authors disclosed financial ties to medical device companies, including Carl Zeiss Meditec, which manufactures the Intrabeam device.<\/p>\n