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THURSDAY, Aug. 20, 2020 (HealthDay News) — Alzheimer disease (AD) may causally influence sleep patterns, but these patterns do not have a causal role in AD, according to a study published online Aug. 19 in Neurology<\/i>.<\/p>\n
Jian Huang, Ph.D., from Imperial College London in the United Kingdom, and colleagues conducted bidirectional two-sample Mendelian randomization analyses to examine the causal relationships between sleep, major depressive disorder (MDD), and AD. Data were included from genome-wide association studies in the U.K. Biobank (446,118 individuals), the Psychiatric Genomics Consortium (18,759 individuals), and the International Genomics of Alzheimer’s Project (63,926 individuals).<\/p>\n
The researchers found that after adjustment for multiple comparisons, the risk for AD was significantly associated with being a morning person (odds ratio, 1.01), shorter sleep duration, being less likely to report long sleep, earlier timing of the least active five hours, and a smaller number of sleep episodes. There was an association for higher risk for AD with a lower risk for insomnia (odds ratio, 0.99). No evidence was found for a causal relationship for either of these abnormal sleep patterns with AD or for a significant causal relationship between MDD and the risk for AD.<\/p>\n
“We found evidence supporting a potential causal influence of AD on sleep disturbances,” the authors write. “However, we did not find evidence supporting a causal role of disturbed sleep patterns on AD, suggesting that observed associations between sleep disorders and AD may be due to reverse causation.”<\/p>\n
One author disclosed financial ties to the biopharmaceutical industry.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n