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TUESDAY, Aug. 18, 2020 (HealthDay News) — Recent-onset diabetes accompanied by weight loss is associated with a substantially increased risk for developing pancreatic cancer, according to a study published online Aug. 13 in JAMA Oncology<\/i>.<\/p>\n
Chen Yuan, Sc.D., from Dana-Farber Cancer Institute in Boston, and colleagues used data from 112,818 women participating in the Nurses’ Health Study and 46,207 men participating in the Health Professionals Follow-Up Study to evaluate the association of diabetes duration and recent weight change with the subsequent risk for pancreatic cancer.<\/p>\n
The researchers identified 1,116 incident cases of pancreatic cancer. Participants with recent-onset diabetes had a higher age-adjusted risk for pancreatic cancer (hazard ratio [HR], 2.97), as did those with long-standing diabetes (HR, 2.16), compared with participants without diabetes. Participants who reported 1 to 4 pounds of weight loss had a higher age-adjusted risk for pancreatic cancer (HR, 1.25), as did those with 5 to 8 pounds of weight loss (HR, 1.33) and those with more than an 8-pound weight loss (HR, 1.92) compared with those with no weight loss. Participants with recent-onset diabetes plus weight loss of 1 to 8 pounds had still higher risk (HR, 3.61), as did those with more than 8 pounds of weight loss (HR, 6.75) compared with those with neither exposure.<\/p>\n
“Individuals with recent-onset diabetes accompanied by weight loss have a high risk for developing pancreatic cancer and may be a group for whom early detection strategies would be advantageous,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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