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WEDNESDAY, Aug. 5, 2020 (HealthDay News) — Years of education and the \u03b54 risk allele at APOE<\/i> influence \u03b2-amyloid pathology in asymptomatic individuals with a parental history of sporadic Alzheimer disease (AD), while only years of education influence \u03b2-amyloid pathology in presymptomatic autosomal dominant AD mutation carriers, according to a study published online Aug. 5 in Neurology<\/i>.<\/p>\n
Julie Gonneaud, Ph.D., from McGill University in Montreal, and colleagues analyzed cross-sectional data from 106 asymptomatic individuals with a parental history of sporadic AD and 117 presymptomatic autosomal dominant AD mutation carriers. The influence of years of education, APOE<\/i>-\u03b54 status, and their interaction on \u03b2-amyloid positron emission tomography was examined in each cohort.<\/p>\n
The researchers found that increased \u03b2-amyloid burden was associated with APOE<\/i>-\u03b54 carriage and a lower level of education for asymptomatic individuals with a parental history of sporadic AD; no interaction was seen between these. There was no relation between APOE<\/i>-\u03b54 and \u03b2-amyloid burden among presymptomatic mutation carriers of autosomal dominant AD; however, increasing level of education was associated with decreased \u03b2-amyloid burden. In the two cohorts, there was a similar association between educational attainment and \u03b2-amyloid burden.<\/p>\n
“These results add to the growing literature suggesting that preventive strategies targeting environmental\/modifiable risk factors could prevent, or at least delay, AD cases,” the authors write.<\/p>\n
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