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FRIDAY, April 13, 2018 (HealthDay News) — For current alcohol drinkers, the threshold for the lowest risk of all-cause mortality is about 100 g\/week, according to a review published in the April 14 issue of The Lancet<\/i>.<\/p>\n
Angela M. Wood, Ph.D., from the University of Cambridge in the United Kingdom, and colleagues conducted a combined analysis of individual-participant data from three large scale data sources in 19 high-income countries. Dose-response associations and calculated hazard ratios were characterized per 100 g per week of alcohol across 83 prospective studies.<\/p>\n
During 5.4 million person-years of follow-up, the researchers identified 40,310 deaths and 39,018 incident cardiovascular disease events in the 599,912 current drinkers included in the analysis. There was a positive and curvilinear association for all-cause mortality with the level of alcohol consumption; the minimum mortality risk was seen for around or below 100 g per week. There was a roughly linear association for alcohol consumption with higher risk of stroke, coronary disease excluding myocardial infarction, heart failure, fatal hypertensive disease, and fatal aortic aneurysm (hazard ratio per 100 g per week higher consumption: 1.14, 1.06, 1.09, 1.24, and 1.15, respectively). Increased alcohol consumption was log-linearly associated with reduced risk of myocardial infarction (hazard ratio, 0.94).<\/p>\n
“These data support limits for alcohol consumption that are lower than those recommended in most current guidelines,” the authors write.<\/p>\n
Several authors disclosed financial ties to the biopharmaceutical and nutrition industries.<\/p>\n
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