<\/b><\/p>\n
<\/b><\/p>\n
MONDAY, July 13, 2020 (HealthDay News) — In early life, maternal history of allergies and asthma confers a stronger effect on a child’s risk for developing the same traits compared with the father’s history, according to a study published online July 7 in Clinical & Experimental Allergy<\/i>.<\/p>\n
Ann-Marie Malby Schoos, M.D., Ph.D., from the University of Copenhagen in Denmark, and colleagues investigated parent-specific effects on risk for developing allergic sensitization and asthma in childhood using data from 685 parent-child trios participating in the Copenhagen Prospective Studies on Asthma in Childhood 2010.<\/p>\n
The researchers found that maternal elevated specific immunoglobulin (Ig)E increased the child’s risk for elevated specific IgE from 0 to 6 years compared with paternal IgE (adjusted odds ratio [aOR] for mother, 1.49 [95 percent confidence interval (CI), 1.09 to 2.03; P = 0.01]; aOR for father, 1.32 [95 percent CI, 0.96 to 1.82; P = 0.08]). There was also an association seen between maternal elevated total IgE and increased child’s risk for elevated total IgE (aOR, 4.32; 95 percent CI, 1.51 to 10.8; P < 0.01), and a trend was seen for paternal total IgE (aOR, 2.01; 95 percent CI, 0.76 to 4.82; P = 0.13). The maternal effect was strongest in early life, whereas at age 6 years, the parental effects were comparable. A similar pattern was seen for the child's risk for asthma.<\/p>\n
“This suggests that maternal nongenetic factors seem to confer an added disease risk to the child, particularly in early life,” the authors write.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n