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MONDAY, July 13, 2020 (HealthDay News) — Skin colonization by Staphylococcus aureus<\/i> is associated with the risk for developing atopic dermatitis (AD), and infants who do not develop AD primarily exhibit acquisition of dysfunctional mutations in the S. aureus<\/i> quorum-sensing system, according to a study published in the July 8 issue of Science Translational Medicine<\/i>.<\/p>\n
Yuumi Nakamura, M.D., Ph.D., from the Chiba University Graduate School of Medicine in Japan, and colleagues performed whole-genome sequencing of S. aureus<\/i> strains isolated from the cheek skin of 268 Japanese infants at 1 to 6 months old to examine the role in AD development.<\/p>\n
The researchers found that regardless of AD outcome, about 45 percent of infants were colonized with S. aureus<\/i> at 1 month. At 6 months of age, skin colonization with S. aureus<\/i> was associated with an increased risk for developing AD. Strains from 6-month-old infants who did not develop AD primarily exhibited acquisition of dysfunctional mutations in the S. aureus<\/i> Agr quorum-sensing system. In mice, expression of a functional Agr system in S. aureus<\/i> was necessary for epidermal colonization and AD-like inflammation induction.<\/p>\n
“These studies show that retention of agr<\/i> virulence is associated with increased S. aureus<\/i> skin colonization and development of AD in Japanese infants,” the authors write.<\/p>\n
One author disclosed financial ties to Boehringer Ingelheim.<\/p>\n
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