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THURSDAY, April 12, 2018 (HealthDay News) — For patients with breast cancer, endocrine therapy-induced alopecia (EIA) has a pattern that is similar to androgenetic alopecia, according to a study published online April 11 in JAMA Dermatology<\/i>.<\/p>\n
Azael Freites-Martinez, M.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues conducted a retrospective cohort study to characterize EIA in 112 patients with breast cancer, diagnosed with EIA from Jan. 1, 2009, to Dec. 31, 2016.<\/p>\n
The researchers found that in 67 and 33 percent of patients, alopecia was attributed to aromatase inhibitors and tamoxifen, respectively. Ninety-two percent of patients had grade 1 severity, and the pattern was similar to androgenetic alopecia. At baseline, the predominant trichoscopic feature was the presence of vellus hairs and intermediate- and thick-diameter terminal hair shafts. There was a negative impact on quality of life; according to the Hairdex score, there was a higher effect in the emotion domain. Eighty percent of the 46 patients assessed for response to minoxidil had moderate or significant improvement in alopecia after treatment.<\/p>\n
“Endocrine therapies are associated with a pattern alopecia similar to androgenetic-type, consistent with the mechanism of action of causal agents,” the authors write. “A significant negative impact on quality of life was reported by patients, despite mostly mild alopecia severity.”<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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