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FRIDAY, June 12, 2020 (HealthDay News) — Among older adults, dysanapsis, a mismatch of airway tree caliber to lung size, measured by computed tomography (CT) is associated with chronic obstructive pulmonary disease (COPD), according to a study published in the June 9 issue of the Journal of the American Medical Association<\/i>.<\/p>\n
Benjamin M. Smith, M.D., from the Columbia University Medical Center in New York City, and colleagues conducted a retrospective cohort study of two samples (the Multi-Ethnic Study of Atherosclerosis [MESA] Lung Study with 2,531 participants and the Canadian Cohort of Obstructive Lung Disease [CanCOLD] with 1,272 participants) to examine whether dysanapsis assessed by CT is associated with incident COPD in older adults.<\/p>\n
The researchers found that in the MESA Lung sample, 9.4 percent of participants had prevalent COPD, and of those without prevalent COPD, 4.3 percent had incident COPD at a median of 6.2 years. Participants in the lowest versus the highest quartile of airway-to-lung ratio had significantly higher COPD incidence (rate ratio, 8.12) but no significant difference in forced expiratory volume in one second (FEV1<\/sub>) decline. Fifteen percent of CanCOLD participants had incident COPD at a median of 3.1 years. Incidence was significantly higher in the lowest versus the highest airway-to-lung quartile (risk ratio, 3.33), with no significant difference in FEV1<\/sub> decline.<\/p>\n “These observations suggest that dysanapsis quantified as the airway to lung ratio on CT is a risk factor for COPD among older adults,” the authors write.<\/p>\n Several authors disclosed financial ties to the biopharmaceutical and medical device industries.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n