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TUESDAY, April 10, 2018 (HealthDay News) — One night of sleep deprivation is associated with amyloid-\u03b2 (A\u03b2) burden (ABB) in healthy controls, according to a study published online April 9 in the Proceedings of the National Academy of Sciences<\/i>.<\/p>\n
Using positron emission tomography and 18<\/sup>F-florbetaben, Ehsan Shokri-Kojori, Ph.D., from the National Institutes of Health in Bethesda, Md., and colleagues measured brain ABB in 20 healthy controls tested after a night of rested sleep (baseline) and a night of sleep deprivation.<\/p>\n The researchers found that relative to baseline, one night of sleep deprivation resulted in a significant increase in ABB in the right hippocampus and thalamus. These increases were associated with mood worsening after sleep deprivation; however, they were not associated with the genetic risk for Alzheimer’s disease (APOE<\/i> genotype). There was an inverse association for baseline ABB in a range of subcortical regions and the precuneus with reported night sleep hours. There was also a correlation for APOE<\/i> genotyping with subcortical ABB.<\/p>\n “Our findings show adverse effects of one-night sleep deprivation on brain ABB and expand on prior findings of higher A\u03b2 accumulation with chronic less sleep,” the authors write.<\/p>\n One author was an employee of Piramal Pharma, which partially supported the radiotracer for the study.<\/p>\n