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FRIDAY, May 15, 2020 (HealthDay News) — For patients with metastatic urothelial carcinoma, the addition of atezolizumab to platinum-based chemotherapy prolongs progression-free survival, according to a study published online May 14 in The Lancet<\/i>.<\/p>\n
Matthew D. Galsky, M.D., from the Icahn School of Medicine at Mount Sinai and the Tisch Cancer Institute in New York City, and colleagues conducted a randomized trial involving untreated patients with locally advanced or metastatic urothelial carcinoma from 221 sites in 35 countries. A total of 1,213 patients were enrolled and randomly assigned to receive atezolizumab plus platinum-based chemotherapy (group A; 451 patients), atezolizumab monotherapy (group B; 362 patients), or placebo plus platinum-based chemotherapy (group C; 400 patients).<\/p>\n
For all patients, the median follow-up for survival was 11.8 months. The researchers found that the median progression-free survival was 8.2 months and 6.3 months in groups A and C, respectively, in the intention-to-treat population (stratified hazard ratio, 0.82; 95 percent confidence interval, 0.70 to 0.96). The median overall survival was 16.0 and 13.4 months in groups A and C, respectively (stratified hazard ratio, 0.83; 95 percent confidence interval, 0.69 to 1.00). The median overall survival was 15.7 and 13.1 months for groups B and C, respectively (stratified hazard ratio, 1.02; 95 percent confidence interval, 0.83 to 1.24).<\/p>\n
“These results support the use of atezolizumab plus platinum-based chemotherapy as a potential firstline treatment option for metastatic urothelial carcinoma,” the authors write.<\/p>\n
Several authors disclosed financial ties to pharmaceutical companies, including F. Hoffmann-La Roche\/ Genentech, which manufactures atezolizumab and funded the study.<\/p>\n
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