<\/b><\/p>\n
<\/b><\/p>\n
THURSDAY, May 7, 2020 (HealthDay News) — For patients with low-grade upper tract urothelial cancer, primary chemoablation with intracavitary UGN-101, a mitomycin-containing reverse thermal gel, results in clinically significant disease eradication, according to a study published online April 29 in The Lancet Oncology<\/i>.<\/p>\n
Nir Kleinmann, M.D., from Sheba Medical Center in Ramat Gan, Israel, and colleagues conducted an open-label, single-arm, phase 3 trial involving participants from 24 academic sites in the United States and Israel. Participants with primary or recurrent biopsy-proven, low-grade upper tract urothelial cancer were registered to receive six instillations of once-weekly UGN-101 via retrograde catheter to the renal pelvis and calyces. Four to six weeks after completion of initial therapy, all patients had a planned primary disease evaluation.<\/p>\n
Seventy-one of 74 enrolled patients received at least one dose of UGN-101 between April 6, 2017, and Nov. 26, 2018. The researchers found that at the primary disease evaluation visit, 42 patients (59 percent) had a complete response. For patients with a complete response, the median follow-up was 11.0 months. The most frequently reported adverse events were ureteric stenosis, urinary tract infection, hematuria, flank pain, and nausea (44, 32, 31, 30, and 24 percent, respectively). Twenty-seven percent of patients had study drug-related or procedure-related serious adverse events.<\/p>\n
“This novel kidney-sparing approach might offer an important alternative for patients with low-grade upper tract urothelial cancer and expand the treatment options for patients with tumors that are difficult to treat endoscopically,” the authors write.<\/p>\n
Several authors disclosed financial ties to biopharmaceutical companies, including UroGen Pharma, which funded the study.<\/p>\n
Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n