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TUESDAY, May 5, 2020 (HealthDay News) — L-thyroxine does not improve hypothyroid symptoms or tiredness among older adults with subclinical hypothyroidism (SCH) and high symptom burden, according to a study published online May 5 in the Annals of Internal Medicine<\/i>.<\/p>\n
Maria de Montmollin, M.D., from the Bern University Hospital in Switzerland, and colleagues examined whether L-thyroxine improves hypothyroid symptoms and tiredness among older adults with SCH and greater symptom burden in a secondary analysis of a randomized trial. Data were included for 638 participants aged 65 years or older with persistent SCH; 132 had hypothyroid symptoms scores greater than 30, and 133 had tiredness scores greater than 40.<\/p>\n
The researchers found that among adults with high symptom burden, there was similar improvement in the hypothyroid symptoms score for those receiving L-thyroxine and placebo (mean within-group change, \u221212.3 and \u221210.4, respectively, at one year). Similar improvements were also seen between those receiving L-thyroxine and placebo in the tiredness score (mean within-group change, \u22128.9 and \u221210.9, respectively). No evidence was seen for baseline hypothyroid symptoms or tiredness scores modifying the effects of L-thyroxine or placebo.<\/p>\n
“In the absence of another randomized clinical trial specifically designed for persons with SCH and high symptom burden, these results do not support routine L-thyroxine therapy among older adults with SCH, including those with greater hypothyroid symptom burden and tiredness,” the authors write.<\/p>\n
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