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FRIDAY, May 1, 2020 (HealthDay News) — Changes in total lean body mass with aging are associated with the development of diabetes among men and women, according to a study published online April 30 in the Journal of the Endocrine Society<\/i>.<\/p>\n
Rita R. Kalyani, M.D., from Johns Hopkins University in Baltimore, and colleagues examined the association of lean body mass with aging and incident diabetes in a cohort of 871 men and 984 women without diabetes from the Baltimore Longitudinal Study of Aging. Participants were followed for a median of seven years.<\/p>\n
The researchers found that fasting and two-hour glucose as well as prediabetes were lower for men and women with a higher percentage total lean body mass. Among men, comparing the highest versus lowest quartiles, there were inverse associations for percentage total lean body mass, percentage leg lean mass, and lean:fat mass ratio with incident diabetes (hazard ratios, 0.46, 0.38, and 0.39) after accounting for race; the associations were attenuated after adjustment for height and weight. Among women, absolute total lean body mass was positively associated with incident diabetes, with similar trends seen in men.<\/p>\n
“While men with a lower percentage of total lean body mass had a greater incidence of diabetes as we hypothesized, in part related to anthropometrics such as height and weight, both men and women with higher absolute total lean body mass unexpectedly had a greater incidence of diabetes, too, even after accounting for total fat mass measures,” the authors write.<\/p>\n