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FRIDAY, April 17, 2020 (HealthDay News) — The use of probiotics as an adjunct therapy may help in the management of acne vulgaris, according to a review published online April 7 in Dermatologic Therapy<\/i>.<\/p>\n
Azadeh Goodarzi, M.D., from the Iran University of Medical Sciences in Tehran, and colleagues conducted a systematic literature review to assess the potential of probiotics (either oral or topical) for treating acne vulgaris.<\/p>\n
The researchers found that acne lesions were associated with increases in the proportion of Propionibacterium acnes<\/i> (P. acnes<\/i>) as a skin commensal bacterium. Probiotics showed inhibitory effects on P. acnes<\/i> by mediating antibacterial proteins and bacteriocin-like inhibitory substances and having immunomodulatory effects on keratinocytes and epithelial cells. Additionally, probiotics inhibited cytokine interleukin-8 in epithelial cells and keratinocytes, suggesting immunomodulatory activities. Glycerol fermentation by Staphylococcus epidermidis<\/i> acted as a natural skin defense against acne and an overgrowth inhibitor of P. acnes<\/i>. Lactococcus<\/i> sp., as an antimicrobial agent in lotions and cosmetic formulations, can decrease the inflammatory mediators that are produced by P. acnes<\/i> and cause vasodilation, edema, mast cell degranulation and tumor necrosis factor-alpha release.<\/p>\n
“Oral administration of probiotics was found to constitute an adjuvant therapy to conventional modalities for treating mild-to-moderate acne vulgaris,” the authors write.<\/p>\n
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