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MONDAY, March 30, 2020 (HealthDay News) — Among individuals with diabetes, hemoglobin A1c (HbA1c) is associated with cognitive scores after a lacunar stroke, according to a study presented at the virtual meeting of The Endocrine Society, held from March 28 to 31.<\/p>\n
Tali Cukierman-Yaffe, M.D., from Tel Aviv University in Israel, and colleagues examined the effect of baseline and follow-up HbA1c on the baseline and change in Cognitive Assessment Screening Instrument (CASI) scores over time among participants with a median of two cognitive assessments. Data were examined for 942 individuals with diabetes and a lacunar stroke.<\/p>\n
The researchers found an association for each 1 percent higher baseline HbA1c with a 0.06 lower standardized CASI z-score. Higher baseline HbA1c values were associated with a reduced CASI z-score over time. A 1 percent increase in HbA1c over time was associated with a 0.021 decrease in CASI score during follow-up. After adjustment for confounding variables, including age, sex, education, race, depression, hypertension, hyperlipidemia, body mass index, cardiovascular disease, and obstructive sleep apnea, these associations remained statistically significant.<\/p>\n
“Identifying modifiable risk factors that are associated with cognitive dysfunction in people with type 2 diabetes who experience a lacunar stroke has major public health implications,” Cukierman-Yaffe said in a statement.<\/p>\n
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